| Gene Symbol |
Apc2
|
| Entrez Gene |
23805
|
| Alt Symbol |
AI852447, APCL, R75424
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
adenomatosis polyposis coli 2
|
| Other Description |
adenomatous polyposis coli protein 2
|
| Swissprots |
Q9Z1K7
|
| Accessions |
CAA10207 EDL31570 Q9Z1K7 AK140637 AK213778 BC119475 KF481611 AHI88430 XM_006513643 XP_006513706 XM_006513644 XP_006513707 XM_006513645 XP_006513708 XM_006513646 XP_006513709 NM_011789 NP_035919
|
| Function |
Promotes rapid degradation of CTNNB1 and may function as a tumor suppressor. May function in Wnt signaling (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cytoplasm {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Note=Associated with actin filaments and the microtubule network. {ECO:0000250}.
|
| Tissue Specificity |
Expressed in brain and other neural tissues. {ECO:0000269|PubMed:15018807}.
|
| Top Pathways |
Wnt signaling pathway, HTLV-I infection, Endometrial cancer, Colorectal cancer, Hippo signaling pathway
|