Gene Symbol | Apc2 |
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Entrez Gene | 23805 |
Alt Symbol | AI852447, APCL, R75424 |
Species | Mouse |
Gene Type | protein-coding |
Description | adenomatosis polyposis coli 2 |
Other Description | adenomatous polyposis coli protein 2 |
Swissprots | Q9Z1K7 |
Accessions | CAA10207 EDL31570 Q9Z1K7 AK140637 AK213778 BC119475 KF481611 AHI88430 XM_006513643 XP_006513706 XM_006513644 XP_006513707 XM_006513645 XP_006513708 XM_006513646 XP_006513709 NM_011789 NP_035919 |
Function | Promotes rapid degradation of CTNNB1 and may function as a tumor suppressor. May function in Wnt signaling (By similarity). {ECO:0000250}. |
Subcellular Location | Cytoplasm {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Note=Associated with actin filaments and the microtubule network. {ECO:0000250}. |
Tissue Specificity | Expressed in brain and other neural tissues. {ECO:0000269|PubMed:15018807}. |
Top Pathways | Wnt signaling pathway, HTLV-I infection, Endometrial cancer, Colorectal cancer, Hippo signaling pathway |
APC2 CRISPR/Cas9 KO Plasmid (m) - sc-423843 from Santa Cruz Biotechnology
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APC2 HDR Plasmid (m) - sc-423843-HDR from Santa Cruz Biotechnology
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APC2 Double Nickase Plasmid (m) - sc-423843-NIC from Santa Cruz Biotechnology
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APC2 Double Nickase Plasmid (m2) - sc-423843-NIC-2 from Santa Cruz Biotechnology
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APC2 CRISPR Activation Plasmid (m) - sc-423843-ACT from Santa Cruz Biotechnology
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APC2 CRISPR Activation Plasmid (m2) - sc-423843-ACT-2 from Santa Cruz Biotechnology
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APC2 Lentiviral Activation Particles (m) - sc-423843-LAC from Santa Cruz Biotechnology
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APC2 Lentiviral Activation Particles (m2) - sc-423843-LAC-2 from Santa Cruz Biotechnology
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APC2 siRNA (m) - sc-37527 from Santa Cruz Biotechnology
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APC2 shRNA Plasmid (m) - sc-37527-SH from Santa Cruz Biotechnology
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APC2 shRNA (m) Lentiviral Particles - sc-37527-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EMU035841 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN26818 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND26818 from Sigma-Aldrich
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shRNA set against Mouse APC2 (NM_011789.2) - SHH238122 from Creative biogene
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shRNA set against Mouse Apc2(NM_011789.2) - SHG064153 from Creative biogene
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APC2 miRNA 3'UTR clone - MiUTR1M-01566 from Creative biogene
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