DTL

Gene Symbol	DTL
Entrez Gene	51514
Alt Symbol	CDT2, DCAF2, L2DTL, RAMP
Species	Human
Gene Type	protein-coding
Description	denticleless E3 ubiquitin protein ligase homolog (Drosophila)
Other Description	DDB1 and CUL4 associated factor 2|DDB1- and CUL4-associated factor 2|RA regulated nuclear matrix associated protein|RA-regulated nuclear matrix-associated protein|denticleless protein homolog|lethal(2) denticleless protein homolog|retinoic acid-regulated nuclear matrix-associated protein
Swissprots	Q9NWM5 Q9NW34 Q9NW03 Q96SN0 Q9NZJ0 D3DT98 A8K8H8 Q5VT77
Accessions	EAW93395 EAW93396 EAW93397 EAW93398 Q9NZJ0 AF195765 AAF35182 AF345896 AAK54706 AI800751 AK000742 BAA91355 AK001206 BAA91552 AK001261 BAA91586 AK027651 BAB55267 AK292343 BAF85032 AK299649 BAG61569 AK303346 BAG64408 BC033297 AAH33297 BC033540 AAH33540 BF508267 DB070033 DQ641253 ABG23317 JF432257 ADZ15474 XM_011509614 XP_011507916 NM_001286229 NP_001273158 NM_001286230 NP_001273159 NM_016448 NP_057532
Function	Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control, DNA damage response and translesion DNA synthesis. The DCX(DTL) complex, also named CRL4(CDT2) complex, mediates the polyubiquitination and subsequent degradation of CDT1, CDKN1A/p21(CIP1) and SETD8. CDT1 degradation in response to DNA damage is necessary to ensure proper cell cycle regulation of DNA replication. CDKN1A/p21(CIP1) degradation during S phase or following UV irradiation is essential to control replication licensing. SETD8 degradation is also important for a proper regulation of mechanisms such as TGF-beta signaling, cell cycle progression, DNA repair and cell migration. Most substrates require their interaction with PCNA for their polyubiquitination: substrates interact with PCNA via their PIP-box, and those containing the 'K+4' motif in the PIP box, recruit the DCX(DTL) complex, leading to their degradation. In undamaged proliferating cells, the DCX(
Subcellular Location	Nucleus. Nucleus membrane; Peripheral membrane protein; Nucleoplasmic side. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Chromosome. Note=Nuclear matrix-associated protein. Translocates from the interphase nucleus to the metaphase cytoplasm during mitosis.
Tissue Specificity	Expressed in placenta and testis, very low expression seen in skeletal muscle. Detected in all hematopoietic tissues examined, with highest expression in thymus and bone marrow. A low level detected in the spleen and lymph node, and barely detectable level in the peripheral leukocytes. RA treatment down-regulated the expression in NT2 cell. {ECO:0000269|PubMed:11278750, ECO:0000269|PubMed:17106265}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human CDT2 peptide - ab42421 from Abcam Category Peptide

Human CDT2 peptide - ab42422 from Abcam Category Peptide

Human CDT2 protein fragment - ab80154 from Abcam Category Protein Source E. coli Species Human

DTL / CDT2 Antibody Blocking Peptide - LS-E634 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

DTL / CDT2 Antibody Blocking Peptide - LS-E16871 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

DTL-Antibody-Center-Blocking-peptide - BP10973c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

DTL Protein Lysate (APL10184) - APL10184 from Aviva Systems Biology Category Protein Prices $219.00 Sizes 200 µg

DTL Protein Lysate (APL10185) - APL10185 from Aviva Systems Biology Category Protein Prices $219.00 Sizes 200 µg

DTL Blocking Peptide - 33R-9712 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

DTL fusion protein - Ag17547 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

DTL fusion protein - ag3589 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human DTL, His-tagged - DTL-27914TH from Creative Biomart Category Protein Source E. coli

Recombinant Human DTL, His-tagged - DTL-12186H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human Denticleless protein homolog(DTL) - CSB-YP889160HU CSB-EP889160HU CSB-BP889160HU CSB-MP889160HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

CDT2 Recombinant Protein Antigen - NBP1-85283PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

DTL Protein Lysate - orb333166 from Biorbyt Category Protein Prices $400.00 Sizes 200 μg Species Human

DTL Protein Lysate - orb333165 from Biorbyt Category Protein Prices $400.00 Sizes 200 μg Species Human

DTL Peptide, Human - M34GP04578H from Creative Peptides Category Peptide Source Synthetic. Species Human

CDT2 Recombinant Protein Antigen - NBP2-58216PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

Denticleless protein homolog (DTL), Recombinant Protein - MBS1312796 from MyBioSource Category Protein Prices $1,540.00, $1,540.00, $1,770.00, $1,770.00, $2,645.00, $2,645.00, $3,090.00, $3,090.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

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