Gene Symbol | CCNE2 |
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Entrez Gene | 9134 |
Alt Symbol | CYCE2 |
Species | Human |
Gene Type | protein-coding |
Description | cyclin E2 |
Other Description | G1/S-specific cyclin-E2 |
Swissprots | O95439 O96020 |
Accessions | AAV97813 EAW91727 EAW91728 EAW91729 EAW91730 EAW91731 EAW91732 O96020 AA830205 AF091433 AAC80528 AF102778 AAC78145 AF106690 AAD08816 AF112857 AAD08819 BC007015 AAH07015 BC020729 AAH20729 BG720611 BJ990268 DB547256 DQ893494 ABM84420 DQ896366 ABM87365 XM_011517364 XP_011515666 XM_011517365 XP_011515667 XM_011517366 XP_011515668 NM_057749 NP_477097 NM_004702 NM_057735 |
Function | Essential for the control of the cell cycle at the late G1 and early S phase. |
Subcellular Location | Nucleus {ECO:0000269|PubMed:9840943}. |
Tissue Specificity | According to PubMed:9858585, highest levels of expression in adult testis, thymus and brain. Lower levels in placenta, spleen and colon. Consistently elevated levels in tumor- derived cells compared to non-transformed proliferating cells. According to PubMed:9840927: low levels in thymus, prostate, brain, skeletal muscle, and kidney. Elevated levels in lung. According to PubMed:9840943 highly expressed in testis, placenta, thymus and brain. In a lesser extent in small intestine and colon. |
Top Pathways | Oocyte meiosis, Cell cycle, Measles, Viral carcinogenesis, PI3K-Akt signaling pathway |
cyclin E2 CRISPR/Cas9 KO Plasmid (h) - sc-402500 from Santa Cruz Biotechnology
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cyclin E2 HDR Plasmid (h) - sc-402500-HDR from Santa Cruz Biotechnology
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cyclin E2 Double Nickase Plasmid (h) - sc-402500-NIC from Santa Cruz Biotechnology
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cyclin E2 Double Nickase Plasmid (h2) - sc-402500-NIC-2 from Santa Cruz Biotechnology
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cyclin E2 CRISPR Activation Plasmid (h) - sc-402500-ACT from Santa Cruz Biotechnology
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cyclin E2 CRISPR Activation Plasmid (h2) - sc-402500-ACT-2 from Santa Cruz Biotechnology
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cyclin E2 Lentiviral Activation Particles (h) - sc-402500-LAC from Santa Cruz Biotechnology
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cyclin E2 Lentiviral Activation Particles (h2) - sc-402500-LAC-2 from Santa Cruz Biotechnology
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cyclin E2 siRNA (h) - sc-37594 from Santa Cruz Biotechnology
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cyclin E2 shRNA Plasmid (h) - sc-37594-SH from Santa Cruz Biotechnology
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cyclin E2 shRNA (h) Lentiviral Particles - sc-37594-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU072051 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN5636 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND5636 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR12619 from Sigma-Aldrich
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CCNE2 siRNA (Human) - CRH6041 from Cohesion Biosciences
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CCNE2 - MBS8228180 from MyBioSource
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shRNA set against Human CCNE2 (NM_057749.2) - SHH257893 from Creative biogene
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CCNE2 shRNA Plasmid (Human) - CHH6041 from Cohesion Biosciences
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CCNE2 miRNA 3'UTR clone - MiUTR3H-06263 from Creative biogene
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