Aak1

Gene Symbol Aak1
Entrez Gene 269774
Alt Symbol 5530400K14Rik, 9630042K20, AU067724, AU067726, BC028270, C79663, D6Ertd245e, R75501, mKIAA1048
Species Mouse
Gene Type protein-coding
Description AP2 associated kinase 1
Other Description adaptor-associated kinase 1
Swissprots B2RUJ0 Q3UHJ0 Q6ZPZ6 Q80XP6 Q3TY53
Accessions EDK99196 Q3UHJ0 Q6PIU9 AK047445 AK053876 BAC35570 AK077408 AK129272 BAC98082 AK147363 BAE27867 AK158879 BAE34710 AK166107 BC028270 AAH28270 BC033597 BC043125 AAH43125 BC059930 BC141176 AAI41177 BP753891 CA528349 CF723295 XM_006506191 XP_006506254 XM_006506192 XP_006506255 NM_001040106 NP_001035195 NM_177762 NP_808430
Function Regulates clathrin-mediated endocytosis by phosphorylating the AP2M1/mu2 subunit of the adaptor protein complex 2 (AP-2) which ensures high affinity binding of AP-2 to cargo membrane proteins during the initial stages of endocytosis. Isoform 1 and isoform 2 display similar levels of kinase activity towards AP2M1. Regulates phosphorylation of other AP-2 subunits as well as AP-2 localization and AP-2-mediated internalization of ligand complexes. Phosphorylates NUMB and regulates its cellular localization, promoting NUMB localization to endosomes. Binds to and stabilizes the activated form of NOTCH1, increases its localization in endosomes and regulates its transcriptional activity (By similarity). {ECO:0000250}.
Subcellular Location Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Membrane, clathrin-coated pit {ECO:0000250}. Note=Active when found in clathrin-coated pits at the plasma membrane. In neuronal cells, enriched at presynaptic terminals. In non-neuronal cells, enriched at leading edge of migrating cells (By similarity). {ECO:0000250}.

AAK1 Antibody - NBP1-79574 from Novus Biologicals

Prices $139.00, $329.00
Sizes 20 µl, 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: AAK1 Antibody [NBP1-79574] - Mouse Thymus Lysate 1ug/ml Gel Concentration 6-18%

Anti-AAK1 antibody produced in rabbit - SAB2107098 from Sigma-Aldrich

Prices $341.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-AAK1: <B>Cat. No. SAB2107098</B>: Western blot analysis of Aak1 in Mouse Thymus with Aak1 (AP2 associated kinase 1) antibody against the C terminal of Aak1 (50 μg) antibody at 1.0 μg/mL.

Aak1 antibody - C-terminal region (ARP55101_P050) - ARP55101_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Mouse-Aak1-Antibody-Center - AP14604c from Abgent, a WuXi AppTec company

Prices $99.00, $295.00
Sizes 80 µl, 400 µl
Host Rabbit
Clonality Polyclonal
Mouse Aak1 Antibody (Center) (Cat. #AP14604c) western blot analysis in mouse bladder tissue lysates (35ug/lane).This demonstrates the Aak1 antibody detected the Aak1 protein (arrow).

Mouse Aak1 Antibody - middle region (OAAB10928) - OAAB10928 from Aviva Systems Biology

Prices $289.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal

AAK1 antibody - 70R-31935 from Fitzgerald

Prices $275.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Aak1 antibody - 70R-9305 from Fitzgerald

Prices $345.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Mouse Aak1 Antibody - abx028171 from Abbexa

Host Rabbit
Clonality Polyclonal

Anti-AAK1 antibody - STJ72034 from St John's Laboratory Ltd

Host Goat
Clonality Polyclonal

Aak1 Antibody - GWB-MT706D from Genway Biotech

Prices $404.00
Sizes 50 µg
Clonality Polyclonal

Anti-AAK1 (aa 278-306) polyclonal antibody - DPABH-27581 from Creative Diagnostics

Host Rabbit
Clonality Polyclonal

Aak1, Polyclonal Antibody - MBS9214771 from MyBioSource

Prices $155.00, $340.00
Sizes 80 µl, 400 µl
Host Rabbit
Clonality Polyclonal

AAK1 antibody - GTX17021 from GeneTex

Prices $319.00
Sizes 100 μg
Host Rabbit
Clonality Polyclonal
Anti-AAK1 antibody used in Western blot. GTX17021

Aak1 Antibody (F43998) - F43998 from NSJ Bioreagent

Prices $125.00, $299.00
Sizes 80 µl (In 1X PBS, pH 7.4, with 0.09% sodium azide), 400 µl (In 1X PBS, pH 7.4, with 0.09% sodium azide)
Host Rabbit
Clonality Polyclonal
Aak1 antibody western blot analysis in mouse bladder tissue lysate. Predicted molecular weight: ~104kDa.

Mouse Aak1 Antibody - 57-852 from ProSci

Prices $375.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal

Aak1 antibody - C-terminal region : Biotin (ARP55101_P050-Biotin) - ARP55101_P050-Biotin from Aviva Systems Biology

Host Rabbit
Clonality Polyclonal

Aak1 antibody - C-terminal region : FITC (ARP55101_P050-FITC) - ARP55101_P050-FITC from Aviva Systems Biology

Host Rabbit
Clonality Polyclonal

Aak1 antibody - C-terminal region : HRP (ARP55101_P050-HRP) - ARP55101_P050-HRP from Aviva Systems Biology

Host Rabbit
Clonality Polyclonal
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