| Gene Symbol |
Aak1
|
| Entrez Gene |
269774
|
| Alt Symbol |
5530400K14Rik, 9630042K20, AU067724, AU067726, BC028270, C79663, D6Ertd245e, R75501, mKIAA1048
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
AP2 associated kinase 1
|
| Other Description |
adaptor-associated kinase 1
|
| Swissprots |
B2RUJ0 Q3UHJ0 Q6ZPZ6 Q80XP6 Q3TY53
|
| Accessions |
EDK99196 Q3UHJ0 Q6PIU9 AK047445 AK053876 BAC35570 AK077408 AK129272 BAC98082 AK147363 BAE27867 AK158879 BAE34710 AK166107 BC028270 AAH28270 BC033597 BC043125 AAH43125 BC059930 BC141176 AAI41177 BP753891 CA528349 CF723295 XM_006506191 XP_006506254 XM_006506192 XP_006506255 NM_001040106 NP_001035195 NM_177762 NP_808430
|
| Function |
Regulates clathrin-mediated endocytosis by phosphorylating the AP2M1/mu2 subunit of the adaptor protein complex 2 (AP-2) which ensures high affinity binding of AP-2 to cargo membrane proteins during the initial stages of endocytosis. Isoform 1 and isoform 2 display similar levels of kinase activity towards AP2M1. Regulates phosphorylation of other AP-2 subunits as well as AP-2 localization and AP-2-mediated internalization of ligand complexes. Phosphorylates NUMB and regulates its cellular localization, promoting NUMB localization to endosomes. Binds to and stabilizes the activated form of NOTCH1, increases its localization in endosomes and regulates its transcriptional activity (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Membrane, clathrin-coated pit {ECO:0000250}. Note=Active when found in clathrin-coated pits at the plasma membrane. In neuronal cells, enriched at presynaptic terminals. In non-neuronal cells, enriched at leading edge of migrating cells (By similarity). {ECO:0000250}.
|