NCOA2
| Gene Symbol | NCOA2 |
|---|---|
| Entrez Gene | 10499 |
| Alt Symbol | GRIP1, KAT13C, NCoA-2, SRC2, TIF2, bHLHe75 |
| Species | Human |
| Gene Type | protein-coding |
| Description | nuclear receptor coactivator 2 |
| Other Description | class E basic helix-loop-helix protein 75|glucocorticoid receptor-interacting protein-1|hTIF2|transcriptional intermediary factor 2 |
| Swissprots | Q14CD2 Q15596 |
| Accessions | CAH05317 EAW86963 Q15596 AK298528 BAG60730 AK308426 AW504723 BC047111 BC092442 AAH92442 BC114383 AAI14384 CK141607 EF374064 ABN46991 LN607830 CEF49517 X97674 CAA66263 XM_005251128 XP_005251185 XM_005251129 XP_005251186 XM_005251130 XP_005251187 XM_005251131 XP_005251188 XM_005251133 XP_005251190 XM_011517436 XP_011515738 XM_011517437 XP_011515739 XM_011517438 XP_011515740 XM_011517439 XP_011515741 XM_011517440 XP_011515742 XM_011517441 XP_011515743 NM_006540 NP_006531 |
| Function | Transcriptional coactivator for steroid receptors and nuclear receptors. Coactivator of the steroid binding domain (AF- 2) but not of the modulating N-terminal domain (AF-1). Required with NCOA1 to control energy balance between white and brown adipose tissues. Critical regulator of glucose metabolism regulation, acts as RORA coactivator to specifically modulate G6PC expression. Involved in the positive regulation of the transcriptional activity of the glucocorticoid receptor NR3C1 by sumoylation enhancer RWDD3. Positively regulates the circadian clock by acting as a transcriptional coactivator for the CLOCK- ARNTL/BMAL1 heterodimer (By similarity). {ECO:0000250|UniProtKB:Q61026, ECO:0000269|PubMed:23508108, ECO:0000269|PubMed:9430642}. |
| Subcellular Location | Nucleus. |
GRIP-1 CRISPR/Cas9 KO Plasmid (h) - sc-401800 from Santa Cruz Biotechnology
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GRIP-1 HDR Plasmid (h) - sc-401800-HDR from Santa Cruz Biotechnology
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GRIP-1 Double Nickase Plasmid (h) - sc-401800-NIC from Santa Cruz Biotechnology
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GRIP-1 Double Nickase Plasmid (h2) - sc-401800-NIC-2 from Santa Cruz Biotechnology
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GRIP-1 CRISPR Activation Plasmid (h) - sc-401800-ACT from Santa Cruz Biotechnology
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GRIP-1 CRISPR Activation Plasmid (h2) - sc-401800-ACT-2 from Santa Cruz Biotechnology
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GRIP-1 Lentiviral Activation Particles (h) - sc-401800-LAC from Santa Cruz Biotechnology
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GRIP-1 Lentiviral Activation Particles (h2) - sc-401800-LAC-2 from Santa Cruz Biotechnology
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GRIP-1 siRNA (h) - sc-38882 from Santa Cruz Biotechnology
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GRIP-1 shRNA Plasmid (h) - sc-38882-SH from Santa Cruz Biotechnology
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GRIP-1 shRNA (h) Lentiviral Particles - sc-38882-V from Santa Cruz Biotechnology
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GRIP1 RNAi - H00023426-R03 from Novus Biologicals
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GRIP1 RNAi - H00023426-R05 from Novus Biologicals
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NCOA2 RNAi - H00010499-R01 from Novus Biologicals
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GRIP1 RNAi - H00023426-R04 from Novus Biologicals
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GRIP1 RNAi - H00023426-R02 from Novus Biologicals
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GRIP1 RNAi - H00023426-R01 from Novus Biologicals
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CompoZr® Knockout ZFN Kit - CKOZFN15028 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND15028 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR09858 from Sigma-Aldrich
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NCOA2 siRNA (Human) - CRH7135 from Cohesion Biosciences
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shRNA set against Human NCOA2 (NM_006540.2) - SHH350084 from Creative biogene
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shRNA set against Human NCOA2(NM_006540.2) - SHR000758 from Creative biogene
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NCOA2 shRNA Plasmid (Human) - CHH7135 from Cohesion Biosciences
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NCOA2 miRNA 3'UTR clone - MiUTR1H-06688 from Creative biogene
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