Gene Symbol | HMOX2 |
---|---|
Entrez Gene | 3163 |
Alt Symbol | HO-2 |
Species | Human |
Gene Type | protein-coding |
Description | heme oxygenase 2 |
Other Description | heme oxygenase (decycling) 2 |
Swissprots | A8MT35 D3DUD5 O60605 P30519 I3L430 |
Accessions | AAV28730 EAW85299 EAW85300 P30519 AF051306 AAC05297 AK093388 BAG52702 AK222629 BAD96349 AK313660 BC002396 AAH02396 BE561721 BI225653 BM905872 BP329113 BP368949 BP369861 BT019788 AAV38591 CR456760 CAG33041 CR541839 CAG46638 D21243 BAA04789 DA141643 DA694137 DB184091 EU831457 ACE87144 EU831544 ACE86463 S34389 AAB22110 XM_011522473 XP_011520775 XM_011546746 XP_011545048 NM_001127204 NP_001120676 NM_001127205 NP_001120677 NM_001127206 NP_001120678 NM_001286267 NP_001273196 NM_001286268 NP_001273197 NM_001286269 NP_001273198 NM_001286270 NP_001273199 NM_001286271 NP_001273200 NM_002134 NP_002125 |
Function | Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. Heme oxygenase 2 could be implicated in the production of carbon monoxide in brain where it could act as a neurotransmitter. |
Subcellular Location | Microsome. Endoplasmic reticulum. |
Top Pathways | Mineral absorption, Porphyrin and chlorophyll metabolism |