| Gene Symbol |
PIAS2
|
| Entrez Gene |
9063
|
| Alt Symbol |
ARIP3, DIP, MIZ, MIZ1, PIASX, PIASX-ALPHA, PIASX-BETA, SIZ2, ZMIZ4
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
protein inhibitor of activated STAT, 2
|
| Other Description |
DAB2-interacting protein|E3 SUMO-protein ligase PIAS2|androgen receptor-interacting protein 3|msx-interacting zinc finger protein|protein inhibitor of activated STAT X|zinc finger, MIZ-type containing 4
|
| Swissprots |
O75928 O75927 Q96KE3 Q96BT5
|
| Accessions |
EAX01484 EAX01485 EAX01486 EAX01487 EAX01488 O75928 AA701927 AF077953 AAC36704 AF077954 AAC36705 AF361054 AAK48938 AK294801 BAG57921 AK308143 AW016227 BC015190 AAH15190 BC111060 AAI11061 BG718291 BX646432 DQ896421 ABM87420 EU176432 ABW03883 XM_005258377 XP_005258434 XM_005258379 XP_005258436 XM_005258381 XP_005258438 XM_005258382 XP_005258439 XM_006722571 XP_006722634 XM_006722572 XP_006722635 XM_006722573 XP_006722636 XM_011526258 XP_011524560 XM_011526259 XP_011524561 NM_004671 NP_004662 NM_173206 NP_775298
|
| Function |
Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulator in various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway. The effects of this transcriptional coregulation, transactivation or silencing may vary depending upon the biological context and the PIAS2 isoform studied. However, it seems to be mostly involved in gene silencing. Binds to sumoylated ELK1 and enhances its transcriptional activity by preventing recruitment of HDAC2 by ELK1, thus reversing SUMO-mediated repression of ELK1 transactivation activity. Isoform PIAS2-beta, but not isoform PIAS2-alpha, promotes MDM2 sumoylation. Isoform PIAS2-alpha promotes PARK7 sumoylation. Isoform PIAS2-beta promotes NCOA2 sumoylation more efficiently than isoform PIAS2- alpha. Isoform PIAS2-alpha sumoylates PML at'Lys-65' and 'L
|
| Subcellular Location |
Nucleus speckle. Nucleus, PML body. Note=Colocalizes at least partially with promyelocytic leukemia nuclear bodies (PML NBs).
|
| Tissue Specificity |
Mainly expressed in testis. Isoform 3 is expressed predominantly in adult testis, weakly in pancreas, embryonic testis and sperm, and at very low levels in other organs. {ECO:0000269|PubMed:11439351, ECO:0000269|PubMed:15301740, ECO:0000269|PubMed:9920921}.
|
| Top Pathways |
Ubiquitin mediated proteolysis, Jak-STAT signaling pathway, Small cell lung cancer
|