| Gene Symbol | TEK |
|---|---|
| Entrez Gene | 7010 |
| Alt Symbol | CD202B, TIE-2, TIE2, VMCM, VMCM1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | TEK tyrosine kinase, endothelial |
| Other Description | angiopoietin-1 receptor|endothelial tyrosine kinase|tunica interna endothelial cell kinase|tyrosine kinase with Ig and EGF homology domains-2|tyrosine-protein kinase receptor TEK|tyrosine-protein kinase receptor TIE-2 |
| Swissprots | Q5TCU2 B4DHD3 D3DRK5 B4DH20 Q8IV34 E7EWI2 Q02763 A8K6W0 |
| Accessions | ADK23807 ADK23808 ADK23809 ADK23810 ADK23811 EAW58571 EAW58572 Q02763 AB086825 BAC45250 AB208796 BAD92033 AK291775 BAF84464 AK294887 BAG57981 AK295043 BAG58094 AK308447 AW020953 BC035514 AAH35514 BU753127 CA392256 DC322431 DC324016 DQ892122 ABM83048 EU176548 ABW03349 EU826591 ACF47627 EU826592 ACF47628 H25908 L06139 AAA61139 XM_005251561 XP_005251618 XM_005251563 XP_005251620 NM_000459 NP_000450 NM_001290077 NP_001277006 NM_001290078 NP_001277007 |
| Function | Tyrosine-protein kinase that acts as cell-surface receptor for ANGPT1, ANGPT2 and ANGPT4 and regulates angiogenesis, endothelial cell survival, proliferation, migration, adhesion and cell spreading, reorganization of the actin cytoskeleton, but also maintenance of vascular quiescence. Has anti-inflammatory effects by preventing the leakage of proinflammatory plasma proteins and leukocytes from blood vessels. Required for normal angiogenesis and heart development during embryogenesis. Required for post- natal hematopoiesis. After birth, activates or inhibits angiogenesis, depending on the context. Inhibits angiogenesis and promotes vascular stability in quiescent vessels, where endothelial cells have tight contacts. In quiescent vessels, ANGPT1 oligomers recruit TEK to cell-cell contacts, forming complexes with TEK molecules from adjoining cells, and this leads to preferential activation of phosphatidylinositol 3-kinase and the AKT1 signaling cascades. In migrating endothelial cells tha |
| Subcellular Location | Cell membrane; Single-pass type I membrane protein. Cell junction. Cell junction, focal adhesion. Cytoplasm, cytoskeleton. Secreted. Note=Recruited to cell-cell contacts in quiescent endothelial cells. Colocalizes with the actin cytoskeleton and at actin stress fibers during cell spreading. Recruited to the lower surface of migrating cells, especially the rear end of the cell. Proteolytic processing gives rise to a soluble extracellular domain that is secreted. |
| Tissue Specificity | Detected in umbilical vein endothelial cells. Proteolytic processing gives rise to a soluble extracellular domain that is detected in blood plasma (at protein level). Predominantly expressed in endothelial cells and their progenitors, the angioblasts. Has been directly found in placenta and lung, with a lower level in umbilical vein endothelial cells, brain and kidney. {ECO:0000269|PubMed:11806244, ECO:0000269|PubMed:8382358}. |
| Top Pathways | Rheumatoid arthritis, PI3K-Akt signaling pathway, Rap1 signaling pathway |