TEK

Gene Symbol	TEK
Entrez Gene	7010
Alt Symbol	CD202B, TIE-2, TIE2, VMCM, VMCM1
Species	Human
Gene Type	protein-coding
Description	TEK tyrosine kinase, endothelial
Other Description	angiopoietin-1 receptor|endothelial tyrosine kinase|tunica interna endothelial cell kinase|tyrosine kinase with Ig and EGF homology domains-2|tyrosine-protein kinase receptor TEK|tyrosine-protein kinase receptor TIE-2
Swissprots	Q5TCU2 B4DHD3 D3DRK5 B4DH20 Q8IV34 E7EWI2 Q02763 A8K6W0
Accessions	ADK23807 ADK23808 ADK23809 ADK23810 ADK23811 EAW58571 EAW58572 Q02763 AB086825 BAC45250 AB208796 BAD92033 AK291775 BAF84464 AK294887 BAG57981 AK295043 BAG58094 AK308447 AW020953 BC035514 AAH35514 BU753127 CA392256 DC322431 DC324016 DQ892122 ABM83048 EU176548 ABW03349 EU826591 ACF47627 EU826592 ACF47628 H25908 L06139 AAA61139 XM_005251561 XP_005251618 XM_005251563 XP_005251620 NM_000459 NP_000450 NM_001290077 NP_001277006 NM_001290078 NP_001277007
Function	Tyrosine-protein kinase that acts as cell-surface receptor for ANGPT1, ANGPT2 and ANGPT4 and regulates angiogenesis, endothelial cell survival, proliferation, migration, adhesion and cell spreading, reorganization of the actin cytoskeleton, but also maintenance of vascular quiescence. Has anti-inflammatory effects by preventing the leakage of proinflammatory plasma proteins and leukocytes from blood vessels. Required for normal angiogenesis and heart development during embryogenesis. Required for post- natal hematopoiesis. After birth, activates or inhibits angiogenesis, depending on the context. Inhibits angiogenesis and promotes vascular stability in quiescent vessels, where endothelial cells have tight contacts. In quiescent vessels, ANGPT1 oligomers recruit TEK to cell-cell contacts, forming complexes with TEK molecules from adjoining cells, and this leads to preferential activation of phosphatidylinositol 3-kinase and the AKT1 signaling cascades. In migrating endothelial cells tha
Subcellular Location	Cell membrane; Single-pass type I membrane protein. Cell junction. Cell junction, focal adhesion. Cytoplasm, cytoskeleton. Secreted. Note=Recruited to cell-cell contacts in quiescent endothelial cells. Colocalizes with the actin cytoskeleton and at actin stress fibers during cell spreading. Recruited to the lower surface of migrating cells, especially the rear end of the cell. Proteolytic processing gives rise to a soluble extracellular domain that is secreted.
Tissue Specificity	Detected in umbilical vein endothelial cells. Proteolytic processing gives rise to a soluble extracellular domain that is detected in blood plasma (at protein level). Predominantly expressed in endothelial cells and their progenitors, the angioblasts. Has been directly found in placenta and lung, with a lower level in umbilical vein endothelial cells, brain and kidney. {ECO:0000269|PubMed:11806244, ECO:0000269|PubMed:8382358}.
Top Pathways	Rheumatoid arthritis, PI3K-Akt signaling pathway, Rap1 signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human TIE2 (mutated R849 W) protein fragment - ab186089 from Abcam Category Protein Prices $436.00 Sizes 10 µg Source Baculovirus infected sf9 cells Species Human

Active human TIE2 full length protein - ab73626 from Abcam Category Protein Prices $302.00 Sizes 10 µg Source Baculovirus infected sf9 cells Species Human

Active human TIE2 protein fragment - ab129039 from Abcam Category Protein Prices $585.00 Sizes 10 µg Source Insect cells Species Human

Active human TIE2 protein fragment - ab196080 from Abcam Category Protein Prices $612.00 Sizes 10 µg Source Baculovirus infected sf9 cells Species Human

Active human TIE2 protein fragment - ab42613 from Abcam Category Protein Prices $321.00 Sizes 10 µg Source Baculovirus infected sf9 cells Species Human

Human TIE2/Fc Chimera - ab54435 from Abcam Source Insect cells Species Human

Human TIE2 peptide - ab71711 from Abcam Category Peptide

Human TIE2 protein fragment - ab159669 from Abcam Category Protein Source Wheat germ Species Human

Mouse TIE2 protein fragment - ab54456 from Abcam Category Protein Source CHO Species Mouse

Mouse TIE2 protein fragment - ab73627 from Abcam Category Protein Source CHO Species Mouse

TEK / TIE2 Antibody Blocking Peptide - LS-E9188 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Tie-2 Partial Recombinant Protein - H00007010-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Tie-2 Recombinant Protein - P3926 from Novus Biologicals Category Protein Prices $1,559.00 Sizes 5 µg Species Human

Tie-2 Recombinant Protein - P4784 from Novus Biologicals Category Protein Prices $1,559.00 Sizes 100 µg Species Human

Tie-2 Peptide - P1692 from Novus Biologicals Category Peptide Species Human

Tie-2 Peptide - P2724 from Novus Biologicals Category Peptide Species Human

TEK-TIE2-Antibody-C-term-Blocking-peptide - BP7684a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Recombinant Human Tie-2 Fc Chimera, CF - 313-TI-100 from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived

TIE2 Fc Protein (OPPA01161) - OPPA01161 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 2 µg Source Insect Cells

Human Tie2 Fc His tag protein - orb83130 from Biorbyt Category Protein Prices $510.00, $748.00 Sizes 100 μg, 200 μg Source Human Species Human

Human Tie2 protein (GST Tag) - orb139741 from Biorbyt Category Protein Prices $323.00, $646.00 Sizes 20 μg, 100 μg Source Baculovirus-Insect Cells Species Human

Human Tie2 His tag protein - orb83277 from Biorbyt Category Protein Prices $400.00, $612.00 Sizes 100 μg, 200 μg Source Human Species Human

Cynomolgus Tie2 protein - orb139744 from Biorbyt Category Protein Prices $434.00, $612.00 Sizes 100 μg, 200 μg Source Human Cells

TIE2 protein (Fc Chimera) - 30R-AT057 from Fitzgerald Category Protein Prices $395.00 Sizes 100 µg Source Sf-9 insect cells

TIE2 (phospho-Tyr1108) Blocking Peptide - abx063337 from Abbexa Category Peptide Species Human, Mouse, Rat, Bovine, Zebrafish

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