PPP2R4

Gene Symbol PPP2R4
Entrez Gene 5524
Alt Symbol PP2A, PR53, PTPA
Species Human
Gene Type protein-coding
Description protein phosphatase 2A activator, regulatory subunit 4
Other Description PP2A phosphatase activator|PP2A subunit B' isoform PR53|phosphotyrosyl phosphatase activator|protein phosphatase 2A, regulatory subunit B' (PR 53)|serine/threonine-protein phosphatase 2A activator|serine/threonine-protein phosphatase 2A regulatory subunit B'
Swissprots Q15258 Q15257 Q9NNZ7 B4DXM4 Q9NNZ9 Q53GZ3 Q9NNZ8 A2A347 Q5TZQ2 Q9BUK1 A9IZU4
Accessions AAF24143 CAA60163 CAB77601 CAB77602 CAB77603 EAW87876 EAW87877 EAW87878 EAW87879 EAW87880 EAW87881 EAW87882 EAW87883 EAW87884 EAW87885 Q15257 AK097317 AK222788 BAD96508 AK293296 BAG56817 AK297202 BAG59687 AK302043 BAG63436 AK302897 BAG64070 AK307424 AK310328 AK310543 AU125192 AU133279 BC002545 AAH02545 BC010497 BC011605 AAH11605 BC020581 BE732116 BG255640 BQ896712 BT020119 AAV38922 CD630703 CR749810 CAH18670 DA052599 DA387148 DA737954 DB009663 DC375389 DQ574284 DQ585074 DQ593084 DQ600004 DQ892154 ABM83080 DQ894879 ABM85805 DQ895349 ABM86275 X73478 CAA51873 XM_011518834 XP_011517136 XM_011518835 XP_011517137 XM_011518836 XP_011517138 XM_011518837 XP_011517139 XM_011518838 XP_011517140 NM_001193397 NP_001180326 NM_001271832 NP_001258761 NM_021131 NP_066954 NM_178000 NP_821067 NM_178001 NP_821068 NM_178003 NP_821070 NM_178002
Function PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Acts as a regulatory subunit for serine/threonine- protein phosphatase 2A (PP2A) modulating its activity or substrate specificity, probably by inducing a conformational change in the catalytic subunit, a proposed direct target of the PPIase. Can reactivate inactive phosphatase PP2A-phosphatase methylesterase complexes (PP2A(i)) in presence of ATP and Mg(2+) (By similarity). Reversibly stimulates the variable phosphotyrosyl phosphatase activity of PP2A core heterodimer PP2A(D) in presence of ATP and Mg(2+) (in vitro). The phosphotyrosyl phosphatase activity is dependent of an ATPase activity of the PP2A(D):PPP2R4 complex. Is involved in apoptosis; the function appears to be independent from PP2A. {ECO:0000250, ECO:0000269|PubMed:16916641, ECO:0000269|PubMed:17333320}.
Subcellular Location Cytoplasm {ECO:0000269|PubMed:17333320}. Nucleus {ECO:0000269|PubMed:17333320}.
Tissue Specificity Widely expressed.

Rat PPP2R4 ELISA Kit (Sandwich ELISA) - LS-F9512 from LifeSpan Bioscience

Category ELISA Kit
Prices $780.00
Sizes 1 plate
Sensitivity 0.057 ng/ml
Range 0.156-10 ng/ml

Protein Phosphatase 2A Activator, Regulatory Subunit 4 (PPP2R4), ELISA Kit - MBS2000097 from MyBioSource

Category ELISA Kit
Prices $405.00, $605.00, $820.00, $3,375.00, $6,125.00
Sizes 24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity Typically less than 0.057ng/mL.
Range 0.156-10ng/mL

ELISA Kit for Protein Phosphatase 2A Activator, Regulatory Subunit 4 (PPP2R4) - SEE026Ra from Uscn Life Science Inc.

Category ELISA Kit
Sensitivity The minimum detectable dose of this kit is typically less than 0.057ng/mL.
Range 0.156-10ng/mL The standard curve concentrations used for the ELISA’s were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

Human PPP2R4 ELISA Kit - E094894 from Biobool

Category ELISA Kit

anti-PPP2R4 / PP2A antibody - ARG64937 from Arigo Biolaboratories

Category ELISA Kit

Protein Phosphatase 2A Activator, Regulatory Subunit 4 (PPP2R4), ELISA Kit - MBS9370352 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Search more