| Gene Symbol |
PPP2R4
|
| Entrez Gene |
5524
|
| Alt Symbol |
PP2A, PR53, PTPA
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
protein phosphatase 2A activator, regulatory subunit 4
|
| Other Description |
PP2A phosphatase activator|PP2A subunit B' isoform PR53|phosphotyrosyl phosphatase activator|protein phosphatase 2A, regulatory subunit B' (PR 53)|serine/threonine-protein phosphatase 2A activator|serine/threonine-protein phosphatase 2A regulatory subunit B'
|
| Swissprots |
Q15258 Q15257 Q9NNZ7 B4DXM4 Q9NNZ9 Q53GZ3 Q9NNZ8 A2A347 Q5TZQ2 Q9BUK1 A9IZU4
|
| Accessions |
AAF24143 CAA60163 CAB77601 CAB77602 CAB77603 EAW87876 EAW87877 EAW87878 EAW87879 EAW87880 EAW87881 EAW87882 EAW87883 EAW87884 EAW87885 Q15257 AK097317 AK222788 BAD96508 AK293296 BAG56817 AK297202 BAG59687 AK302043 BAG63436 AK302897 BAG64070 AK307424 AK310328 AK310543 AU125192 AU133279 BC002545 AAH02545 BC010497 BC011605 AAH11605 BC020581 BE732116 BG255640 BQ896712 BT020119 AAV38922 CD630703 CR749810 CAH18670 DA052599 DA387148 DA737954 DB009663 DC375389 DQ574284 DQ585074 DQ593084 DQ600004 DQ892154 ABM83080 DQ894879 ABM85805 DQ895349 ABM86275 X73478 CAA51873 XM_011518834 XP_011517136 XM_011518835 XP_011517137 XM_011518836 XP_011517138 XM_011518837 XP_011517139 XM_011518838 XP_011517140 NM_001193397 NP_001180326 NM_001271832 NP_001258761 NM_021131 NP_066954 NM_178000 NP_821067 NM_178001 NP_821068 NM_178003 NP_821070 NM_178002
|
| Function |
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Acts as a regulatory subunit for serine/threonine- protein phosphatase 2A (PP2A) modulating its activity or substrate specificity, probably by inducing a conformational change in the catalytic subunit, a proposed direct target of the PPIase. Can reactivate inactive phosphatase PP2A-phosphatase methylesterase complexes (PP2A(i)) in presence of ATP and Mg(2+) (By similarity). Reversibly stimulates the variable phosphotyrosyl phosphatase activity of PP2A core heterodimer PP2A(D) in presence of ATP and Mg(2+) (in vitro). The phosphotyrosyl phosphatase activity is dependent of an ATPase activity of the PP2A(D):PPP2R4 complex. Is involved in apoptosis; the function appears to be independent from PP2A. {ECO:0000250, ECO:0000269|PubMed:16916641, ECO:0000269|PubMed:17333320}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:17333320}. Nucleus {ECO:0000269|PubMed:17333320}.
|
| Tissue Specificity |
Widely expressed.
|