| Gene Symbol |
DGCR8
|
| Entrez Gene |
54487
|
| Alt Symbol |
C22orf12, DGCRK6, Gy1, pasha
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
DGCR8 microprocessor complex subunit
|
| Other Description |
DiGeorge syndrome critical region 8|DiGeorge syndrome critical region gene 8|microprocessor complex subunit DGCR8
|
| Swissprots |
Q6MZE9 Q9NRW2 Q6DCB2 Q6Y2L0 Q9H6T7 Q9H6L8 B2R8G1 Q8WYQ5 Q96GP8 Q96G39
|
| Accessions |
BAB83032 CBM42911 CBV35644 EAX02998 EAX02999 EAX03000 Q8WYQ5 AA737782 AF165527 AAF82263 AK025427 AK025539 BAB15165 AK025780 BAB15238 AK094381 AK222796 BAD96516 AK313357 BAG36158 AM392653 CAL37531 AY189282 AAO86726 BC009323 AAH09323 BC009984 AAH09984 BC037564 BC071568 BC078147 AAH78147 BQ001948 BQ227899 BX649187 CAE46205 CR456356 CAG30242 CU013066 CAK54497 CU013354 CAK54796 DA433651 XM_006724268 XP_006724331 NM_001190326 NP_001177255 NM_022720 NP_073557
|
| Function |
Component of the microprocessor complex that acts as a RNA- and heme-binding protein that is involved in the initial step of microRNA (miRNA) biogenesis. Component of the microprocessor complex that is required to process primary miRNA transcripts (pri-miRNAs) to release precursor miRNA (pre-miRNA) in the nucleus. Within the microprocessor complex, DGCR8 function as a molecular anchor necessary for the recognition of pri-miRNA at dsRNA-ssRNA junction and directs DROSHA to cleave 11 bp away form the junction to release hairpin-shaped pre-miRNAs that are subsequently cut by the cytoplasmic DICER to generate mature miRNAs. The heme-bound DGCR8 dimer binds pri-miRNAs as a cooperative trimer (of dimers) and is active in triggering pri- miRNA cleavage, whereas the heme-free DGCR8 monomer binds pri- miRNAs as a dimer and is much less active. Both double-stranded and single-stranded regions of a pri-miRNA are required for its binding. Involved in the silencing of embryonic stem cells self- ren
|
| Subcellular Location |
Nucleus. Nucleus, nucleolus. Note=Colocalizes with nucleolin and DROSHA in the nucleolus. Mostly detected in the nucleolus as electron-dense granular patches around the fibrillar center (FC) and granular component (GC). Also detected in the nucleoplasm as small foci adjacent to splicing speckles near the chromatin structure. Localized with DROSHA in GW bodies (GWBs), also known as P-bodies.
|
| Tissue Specificity |
Ubiquitously expressed. {ECO:0000269|PubMed:12705904}.
|