| Gene Symbol |
NBR1
|
| Entrez Gene |
4077
|
| Alt Symbol |
1A1-3B, IAI3B, M17S2, MIG19
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
neighbor of BRCA1 gene 1
|
| Other Description |
B-box protein|cell migration-inducing gene 19 protein|membrane component, chromosome 17, surface marker 2 (ovarian carcinoma antigen CA125)|migration-inducing protein 19|next to BRCA1 gene 1 protein
|
| Swissprots |
Q15026 Q13173 Q14596 Q5J7Q8 Q9NRF7 Q96GB6
|
| Accessions |
AAA93228 ABA29210 ABA29213 ABA29216 ABA29219 ABA29222 ABA29225 ABA29228 ABA29231 ABF14461 EAW60946 EAW60947 EAW60948 EAW60949 EAW60950 EAW60951 EAW60952 EAW60953 Q14596 AF227189 AAF74119 AK128512 AK290005 BAF82694 AK297425 BAH12580 AK299328 BAH13002 AK308324 AW874218 AY450308 AAS15047 BC009808 AAH09808 BC012591 BC012847 BM509256 CD673012 D30756 BAA06417 DB081342 HY045337 X76952 CAA54274 XM_006721903 XP_006721966 XM_011524813 XP_011523115 NM_001291571 NP_001278500 NM_001291572 NP_001278501 NM_005899 NP_005890 NM_031862 NP_114068 NM_031858
|
| Function |
Acts probably as a receptor for selective autophagosomal degradation of ubiquitinated targets. {ECO:0000269|PubMed:19250911}.
|
| Subcellular Location |
Cytoplasm. Cytoplasmic vesicle, autophagosome. Lysosome. Cytoplasm, myofibril, sarcomere, M line {ECO:0000250}. Note=In cardiac muscles localizes to the sarcomeric M line (By similarity). Is targeted to lysosomes for degradation. {ECO:0000250}.
|
![Western Blot: NBR1 Overexpression Lysate (Adult Normal) [NBP2-06115] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for NBR1.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/2001_NBR1%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-06115-img0001.jpg)