H2AFB3

Gene Symbol H2AFB3
Entrez Gene 83740
Alt Symbol H2ABBD, H2AFB
Species Human
Gene Type protein-coding
Description H2A histone family, member B3
Other Description H2A Barr body-deficient|H2A.Bbd|histone H2A-Bbd type 2/3|histone variant H2A, Barr-body deficient
Swissprots Q96PR7 P98176 A1L4E4 P0C5Z0 Q6FG78 Q5TZB2
Accessions CAA59998 EAW72649 P0C5Z0 AF254576 AAL01652 BC101409 AAI01410 BC101415 AAI01416 BC101417 AAI01418 BC101418 AAI01419 BC130510 AAI30511 BC130512 AAI30513 BC134365 AAI34366 HQ258044 ADR82798 NM_080720 NP_542451
Function Atypical histone H2A which can replace conventional H2A in some nucleosomes and is associated with active transcription and mRNA processing. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. Nucleosomes containing this histone are less rigid and organize less DNA than canonical nucleosomes in vivo. They are enriched in actively transcribed genes and associate with the elongating form of RNA polymerase. They associate with spliceosome components and are required for mRNA splicing. May participate in spermatogenesis. {ECO:0000269|PubMed:15257289, ECO:0000269|PubMed:16287874, ECO:0000269|PubMed:16957777, ECO:0000269|PubMed:17591702, ECO:0000269|PubMed:17726088, ECO:0000269|PubMed:18329190, ECO:0000269|PubMed:22795134}.
Subcellular Location Nucleus. Chromosome. Note=Associated with the active X chromosome and with autosomes, while it is absent from the inactive X chromosome and excluded from Barr bodies.
Tissue Specificity Present in mature sperm. {ECO:0000269|PubMed:20008104}.
Top Pathways Systemic lupus erythematosus, Alcoholism

Human Histone H2A-Bbd (unmodified ) peptide - ab15024 from Abcam

Category Peptide
Species Human

Human Histone H2A-Bbd protein fragment - ab164435 from Abcam

Category Protein
Source Wheat germ
Species Human
ab164435 on a 12.5% SDS-PAGE stained with Coomassie Blue.

Recombinant Human Histone H2A B3 Protein - H00083740-Q01 from Novus Biologicals

Category Protein
Prices $369.00, $529.00
Sizes 10 µg, 25 µg
Source Wheat Germ
Species Human

H2AB2-Antibody-Center-Blocking-Peptide - BP4766c from Abgent, a WuXi AppTec company

Category Peptide
Prices $80.00
Sizes 100 µg

Histone H2A-Bbd type 2/3 / H2AFB2 - H00083740-Q01-10 from Acris Antibodies

Category Protein
Prices $380.00
Sizes 10 µg
Source in vitro transl.
Species Human

Histone H2A-Bbd type 2/3 / H2AFB2 - H00083740-Q01-25 from Acris Antibodies

Category Protein
Prices $500.00
Sizes 25 µg
Source in vitro transl.
Species Human

H2AFB2 fusion protein - ag16043 from Proteintech Group

Category Protein
Source E. coli-derived, PGEX-4T
Species Human

Recombinant Human Histone H2A-Bbd type 2/3(H2AFB2) - CSB-YP314010HU CSB-EP314010HU CSB-BP314010HU CSB-MP314010HU from Cusabio

Category Protein
Source Yeast or E.coli or Baculovirus or Mammalian cell
Species Human

Histone H2A-Bbd type 2/3 / H2AFB2 - TP323551 from Acris Antibodies

Category Protein
Prices $680.00
Sizes 20 µg
Source HEK293 cells
Species Human
Histone H2A-Bbd type 2/3 / H2AFB2

H2AFB3 Peptide, Human - M34GP06805H from Creative Peptides

Category Peptide
Source Synthetic.
Species Human

Histone H2A-Bbd type 2/3 (H2AFB2), Recombinant Protein - MBS1187937 from MyBioSource

Category Protein
Prices $850.00, $850.00, $1,075.00, $1,075.00, $1,225.00, $1,225.00, $1,685.00, $1,685.00
Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell)
Source E Coli or Yeast or Baculovirus or Mammalian Cell
Species Human

Recombinant Human H2AFB2 Protein, GST-tagged - H2AFB2-4532H from Creative Biomart

Category Protein
Source Wheat Germ
Species Human

Recombinant Human H2AFB3 Protein, GST-tagged - H2AFB3-4533H from Creative Biomart

Category Protein
Source Wheat Germ
Species Human
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