H2AFB3

Gene Symbol H2AFB3
Entrez Gene 83740
Alt Symbol H2ABBD, H2AFB
Species Human
Gene Type protein-coding
Description H2A histone family, member B3
Other Description H2A Barr body-deficient|H2A.Bbd|histone H2A-Bbd type 2/3|histone variant H2A, Barr-body deficient
Swissprots Q96PR7 P98176 A1L4E4 P0C5Z0 Q6FG78 Q5TZB2
Accessions CAA59998 EAW72649 P0C5Z0 AF254576 AAL01652 BC101409 AAI01410 BC101415 AAI01416 BC101417 AAI01418 BC101418 AAI01419 BC130510 AAI30511 BC130512 AAI30513 BC134365 AAI34366 HQ258044 ADR82798 NM_080720 NP_542451
Function Atypical histone H2A which can replace conventional H2A in some nucleosomes and is associated with active transcription and mRNA processing. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. Nucleosomes containing this histone are less rigid and organize less DNA than canonical nucleosomes in vivo. They are enriched in actively transcribed genes and associate with the elongating form of RNA polymerase. They associate with spliceosome components and are required for mRNA splicing. May participate in spermatogenesis. {ECO:0000269|PubMed:15257289, ECO:0000269|PubMed:16287874, ECO:0000269|PubMed:16957777, ECO:0000269|PubMed:17591702, ECO:0000269|PubMed:17726088, ECO:0000269|PubMed:18329190, ECO:0000269|PubMed:22795134}.
Subcellular Location Nucleus. Chromosome. Note=Associated with the active X chromosome and with autosomes, while it is absent from the inactive X chromosome and excluded from Barr bodies.
Tissue Specificity Present in mature sperm. {ECO:0000269|PubMed:20008104}.
Top Pathways Systemic lupus erythematosus, Alcoholism

Histone H2A.Bbd CRISPR/Cas9 KO Plasmid (h) - sc-418460 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Histone H2A.Bbd HDR Plasmid (h) - sc-418460-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Histone H2A.Bbd Double Nickase Plasmid (h) - sc-418460-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Histone H2A.Bbd Double Nickase Plasmid (h2) - sc-418460-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Histone H2A.Bbd CRISPR Activation Plasmid (h) - sc-418460-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Histone H2A.Bbd CRISPR Activation Plasmid (h2) - sc-418460-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Histone H2A.Bbd Lentiviral Activation Particles (h) - sc-418460-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Histone H2A.Bbd Lentiviral Activation Particles (h2) - sc-418460-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Histone H2A B3 RNAi - H00083740-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU231361 from Sigma-Aldrich

Category siRNA
Prices $140.00
Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN9838 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND9838 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

H2AFB3 siRNA (Human) - CRJ3184 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human H2AFB3 (NM_080720.1) - SHH309806 from Creative biogene

Category siRNA
Species Reactivities Human

Human H2AFB2 siRNA - orb278850 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

Human H2AFB3 siRNA - orb273685 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

H2AFB3 shRNA Plasmid (Human) - CHJ3184 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

H2AFB3 miRNA 3'UTR clone - MiUTR4H-TG11395 from Creative biogene

Species Reactivities Human
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