Gene Symbol | Pou2af1 |
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Entrez Gene | 18985 |
Alt Symbol | BOB.1, Bob-1, Bob1, OBF-1, OBF.1, OCA-B, OCAB |
Species | Mouse |
Gene Type | protein-coding |
Description | POU domain, class 2, associating factor 1 |
Other Description | B-cell-specific coactivator OBF-1|OCT-binding factor 1|POU domain class 2-associating factor 1 |
Swissprots | Q64693 |
Accessions | EDL25775 Q64693 AK088587 BAC40437 AK135080 BAE22412 BC058611 AAH58611 U43788 AAC52618 Z54283 CAA91058 NM_011136 NP_035266 |
Function | Transcriptional coactivator that specifically associates with either OCT1 or OCT2. It boosts the OCT1 mediated promoter activity and to a lesser extent, that of OCT2. It has no intrinsic DNA-binding activity. It recognizes the POU domains of OCT1 and OCT2. It is essential for the response of B-cells to antigens and required for the formation of germinal centers. |
Subcellular Location | Nucleus. |
Tissue Specificity | B-cell specific. |
Bob 1 CRISPR/Cas9 KO Plasmid (m) - sc-422346 from Santa Cruz Biotechnology
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Bob 1 HDR Plasmid (m) - sc-422346-HDR from Santa Cruz Biotechnology
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Bob 1 Double Nickase Plasmid (m) - sc-422346-NIC from Santa Cruz Biotechnology
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Bob 1 Double Nickase Plasmid (m2) - sc-422346-NIC-2 from Santa Cruz Biotechnology
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Bob 1 CRISPR Activation Plasmid (m) - sc-422346-ACT from Santa Cruz Biotechnology
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Bob 1 CRISPR Activation Plasmid (m2) - sc-422346-ACT-2 from Santa Cruz Biotechnology
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Bob 1 Lentiviral Activation Particles (m) - sc-422346-LAC from Santa Cruz Biotechnology
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Bob 1 Lentiviral Activation Particles (m2) - sc-422346-LAC-2 from Santa Cruz Biotechnology
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Bob 1 siRNA (m) - sc-29819 from Santa Cruz Biotechnology
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Bob 1 shRNA Plasmid (m) - sc-29819-SH from Santa Cruz Biotechnology
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Bob 1 shRNA (m) Lentiviral Particles - sc-29819-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EMU034981 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN39081 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND39081 from Sigma-Aldrich
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POU2AF1 siRNA (Mouse) - CRM3164 from Cohesion Biosciences
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shRNA set against Mouse POU2AF1 (NM_011136.2) - SHH380020 from Creative biogene
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shRNA set against Mouse Pou2af1(NM_011136.2) - SHR129594 from Creative biogene
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Mouse POU2AF1 siRNA - orb282640 from Biorbyt
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POU2AF1 shRNA Plasmid (Mouse) - CHM3164 from Cohesion Biosciences
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POU2AF1 miRNA 3'UTR clone - MiUTR1M-09430 from Creative biogene
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