PKD2L1

Gene Symbol	PKD2L1
Entrez Gene	9033
Alt Symbol	PCL, PKD2L, PKDL, TRPP3
Species	Human
Gene Type	protein-coding
Description	polycystic kidney disease 2-like 1
Other Description	polycystic kidney disease 2-like 1 protein|polycystin-2 homolog|polycystin-2L1|polycystin-L|polycystin-L1|transient receptor potential cation channel, subfamily P, member 3
Swissprots	Q9UPA2 Q5W039 Q9P0L9 O75972 Q9UP35
Accessions	AAF28108 EAW49833 EAW49834 Q9P0L9 AF053316 AAD51859 AF073481 AAD41638 AF092170 AAD16101 AF094827 AAD08695 BC025665 AAH25665 DQ084244 AAZ31363 DQ891554 ABM82480 DQ894741 ABM85667 HG503202 XM_011540321 XP_011538623 XM_011540322 XP_011538624 XM_011540323 XP_011538625 XM_011540324 XP_011538626 XM_011540325 XP_011538627 XR_945861 NM_001253837 NP_001240766 NM_016112 NP_057196
Function	Pore-forming subunit of a ciliary calcium channel that controls calcium concentration within primary cilia without affecting cytoplasmic calcium concentration. Forms a heterodimer with PKD1L1 in primary cilia and forms a calcium-permeant ciliary channel that regulates sonic hedgehog/SHH signaling and GLI2 transcription. May act as a sour taste receptor by forming a calcium channel with PKD1L3 in gustatory cells; however, its contribution to sour taste perception is unclear in vivo and may be indirect. {ECO:0000269|PubMed:10517637, ECO:0000269|PubMed:19812697, ECO:0000269|PubMed:23212381, ECO:0000269|PubMed:24336289}.
Subcellular Location	Cell projection, cilium membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum {ECO:0000250}. Note=Interaction with PKD1 or PKD1L3 is required for localization to the cell membrane.
Tissue Specificity	Expressed in adult heart, skeletal muscle, brain, spleen, testis, retina and liver. According to PubMed:9748274, expressed at high levels in fetal tissues, including kidney and liver, and down-regulated in adult tissues. According to PubMed:10602361, expressed in fetal brain, but not expressed in fetal lung, liver or kidney. Isoform 4 appears to be expressed only in transformed lymphoblasts. {ECO:0000269|PubMed:10602361, ECO:0000269|PubMed:9748274}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Polycystin-L (D-13) - sc-160678 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Polycystin-L (H-80) - sc-367975 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

Polycystin-L (N-15) - sc-160679 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Polycystin-L (Q-14) - sc-160680 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Anti-PDK2L1 antibody - ab129614 from Abcam Prices $370.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-PDK2L1 antibody - ab56003 from Abcam Prices $370.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-PKD2L1 Antibody (N-Terminus) - LS-C46907 from LifeSpan Bioscience Prices $295.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-PKD2L1 Antibody (aa37-65, APC) - LS-C216791 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-PKD2L1 Antibody (aa37-65, AP) - LS-C216792 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-PKD2L1 Antibody (aa37-65, Azide-free, HRP) - LS-C216795 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-PKD2L1 Antibody (aa37-65, Biotin) - LS-C216793 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-PKD2L1 Antibody (aa37-65, FITC) - LS-C216794 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-PKD2L1 Antibody (aa37-65, PE) - LS-C216796 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-PKD2L1 Antibody (aa36-65) - LS-C324069 from LifeSpan Bioscience Prices $345.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-PKD2L1 Antibody (aa37-65) - LS-C163747 from LifeSpan Bioscience Prices $295.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

PKD2L1 Antibody - NBP1-74104 from Novus Biologicals Prices $369.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

PKD2L1 Antibody - 44260002 from Novus Biologicals Prices $299.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

PKD2L1 Antibody (4F9) - H00009033-M01 from Novus Biologicals Prices $359.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 4F9

PKD2L1 Antibody - NB100-98743 from Novus Biologicals Prices $329.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

ANTI-PKD2L1 (N-TERM) antibody produced in rabbit - SAB1304833 from Sigma-Aldrich Prices $326.50 Sizes 100 µg Host Rabbit Clonality Polyclonal

Monoclonal Anti-PKD2L1 antibody produced in mouse - SAB1403011 from Sigma-Aldrich Prices $347.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 4F9

PKD2L1-Antibody-N-term - AP16416a from Abgent, a WuXi AppTec company Prices $99.00, $295.00 Sizes 80 µl, 400 µl Host Rabbit Clonality Polyclonal

PKD2L1 Antibody - N-terminal region (OAAB11831) - OAAB11831 from Aviva Systems Biology Prices $289.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

PKD2L1 antibody - 70R-19313 from Fitzgerald Prices $375.00 Sizes 50 µl Host Rabbit Clonality Polyclonal

Anti -FLT4 (Fms-like tyrosine kinase 4, Vascular endothelial growth factor receptor 3,VEGFR3) - 030233 from USBiological Life Science Host Mouse Clonality Monoclonal Clone 13B311

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