PKD2L1
| Gene Symbol | PKD2L1 |
|---|---|
| Entrez Gene | 9033 |
| Alt Symbol | PCL, PKD2L, PKDL, TRPP3 |
| Species | Human |
| Gene Type | protein-coding |
| Description | polycystic kidney disease 2-like 1 |
| Other Description | polycystic kidney disease 2-like 1 protein|polycystin-2 homolog|polycystin-2L1|polycystin-L|polycystin-L1|transient receptor potential cation channel, subfamily P, member 3 |
| Swissprots | Q9UPA2 Q5W039 Q9P0L9 O75972 Q9UP35 |
| Accessions | AAF28108 EAW49833 EAW49834 Q9P0L9 AF053316 AAD51859 AF073481 AAD41638 AF092170 AAD16101 AF094827 AAD08695 BC025665 AAH25665 DQ084244 AAZ31363 DQ891554 ABM82480 DQ894741 ABM85667 HG503202 XM_011540321 XP_011538623 XM_011540322 XP_011538624 XM_011540323 XP_011538625 XM_011540324 XP_011538626 XM_011540325 XP_011538627 XR_945861 NM_001253837 NP_001240766 NM_016112 NP_057196 |
| Function | Pore-forming subunit of a ciliary calcium channel that controls calcium concentration within primary cilia without affecting cytoplasmic calcium concentration. Forms a heterodimer with PKD1L1 in primary cilia and forms a calcium-permeant ciliary channel that regulates sonic hedgehog/SHH signaling and GLI2 transcription. May act as a sour taste receptor by forming a calcium channel with PKD1L3 in gustatory cells; however, its contribution to sour taste perception is unclear in vivo and may be indirect. {ECO:0000269|PubMed:10517637, ECO:0000269|PubMed:19812697, ECO:0000269|PubMed:23212381, ECO:0000269|PubMed:24336289}. |
| Subcellular Location | Cell projection, cilium membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum {ECO:0000250}. Note=Interaction with PKD1 or PKD1L3 is required for localization to the cell membrane. |
| Tissue Specificity | Expressed in adult heart, skeletal muscle, brain, spleen, testis, retina and liver. According to PubMed:9748274, expressed at high levels in fetal tissues, including kidney and liver, and down-regulated in adult tissues. According to PubMed:10602361, expressed in fetal brain, but not expressed in fetal lung, liver or kidney. Isoform 4 appears to be expressed only in transformed lymphoblasts. {ECO:0000269|PubMed:10602361, ECO:0000269|PubMed:9748274}. |
Polycystin-L CRISPR/Cas9 KO Plasmid (h) - sc-408701 from Santa Cruz Biotechnology
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Polycystin-L HDR Plasmid (h) - sc-408701-HDR from Santa Cruz Biotechnology
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Polycystin-L Double Nickase Plasmid (h) - sc-408701-NIC from Santa Cruz Biotechnology
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Polycystin-L Double Nickase Plasmid (h2) - sc-408701-NIC-2 from Santa Cruz Biotechnology
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Polycystin-L CRISPR Activation Plasmid (h) - sc-408701-ACT from Santa Cruz Biotechnology
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Polycystin-L CRISPR Activation Plasmid (h2) - sc-408701-ACT-2 from Santa Cruz Biotechnology
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Polycystin-L Lentiviral Activation Particles (h) - sc-408701-LAC from Santa Cruz Biotechnology
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Polycystin-L Lentiviral Activation Particles (h2) - sc-408701-LAC-2 from Santa Cruz Biotechnology
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Polycystin-L siRNA (h) - sc-90835 from Santa Cruz Biotechnology
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Polycystin-L shRNA Plasmid (h) - sc-90835-SH from Santa Cruz Biotechnology
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Polycystin-L shRNA (h) Lentiviral Particles - sc-90835-V from Santa Cruz Biotechnology
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PKD2L1 RNAi - H00009033-R01 from Novus Biologicals
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MISSION® esiRNA - EHU152631 from Sigma-Aldrich
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MISSION® siRNA - SIHK1718 from Sigma-Aldrich
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MISSION® siRNA - SIHK1717 from Sigma-Aldrich
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MISSION® siRNA - SIHK1719 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN16858 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND16858 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR01167 from Sigma-Aldrich
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PKD2L1 siRNA (Human) - CRH5958 from Cohesion Biosciences
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shRNA set against Human PKD2L1 (NM_016112.2) - SHH376400 from Creative biogene
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PKD2L1 shRNA Plasmid (Human) - CHH5958 from Cohesion Biosciences
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PKD2L1 miRNA 3'UTR clone - MiUTR1H-07939 from Creative biogene
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