EGFR

Gene Symbol	EGFR
Entrez Gene	1956
Alt Symbol	ERBB, ERBB1, HER1, NISBD2, PIG61, mENA
Species	Human
Gene Type	protein-coding
Description	epidermal growth factor receptor
Other Description	avian erythroblastic leukemia viral (v-erb-b) oncogene homolog|cell growth inhibiting protein 40|cell proliferation-inducing protein 61|erb-b2 receptor tyrosine kinase 1|proto-oncogene c-ErbB-1|receptor tyrosine-protein kinase erbB-1
Swissprots	Q9H3C9 Q9H2C9 Q9UMD7 Q9UMG5 Q14225 Q9UMD8 O00732 O00688 Q68GS5 P00533 Q92795 Q9BZS2 P06268 Q9GZX1
Accessions	AAA52370 AAA63171 AAC50796 AAC50797 AAC50798 AAC50799 AAC50800 AAC50801 AAC50803 AAC50804 AAG35786 AAG35787 AAG35788 AAG35789 AAG35790 AAG43243 AAG43244 AAG43245 AAS07524 AAS83109 AFK93471 AFK93472 AFK93473 AFK93474 AFK93475 AFK93476 AFK93477 AFK93478 AIE16170 AIE16171 BAE15958 BAF79636 BAF80003 BAF80004 BAL40868 BAL41217 CAA29668 CAA34902 CAJ55813 CAM91181 CAV33298 CBK51921 CBK51922 CBK51923 CBK51924 CCO13722 CCO75437 CCO75439 CCV20014 EAW50962 EAW50963 EAW50964 EAW50965 P00533 AB209442 BAD92679 AF125253 AAG43240 AF277897 AAK01080 AI217671 AK127817 AK225422 AK290352 BAF83041 AK294750 BAH11869 AL598260 AU137334 AW163038 AW295229 AY550966 AAT52212 AY698023 AAT97978 AY698024 AAT97979 BC070081 BC094761 AAH94761 BC118665 AAI18666 BC128419 AAI28420 CB160831 DQ088980 AAZ66620 EF210210 ABQ66237 EF210211 ABQ66238 GU228573 GU228584 GU255993 ADL28125 HM437234 ADN43066 HM437235 HQ730875 HQ912715 ADZ75461 HQ999997 ADY76965 K03193 AAA52371 U48722 AAC50802 U51732 U95089 AAB53063 X00588 CAA25240 X00663 CAA25282 NM_005228 NP_005219 NM_201282 NP_958439 NM_201283 NP_958440 NM_201284 NP_958441
Function	Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, amphiregulin, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS- RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules. May also activate the NF-kappa-B signaling cascade. Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling. Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-ca
Subcellular Location	Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass type I membrane protein. Nucleus membrane; Single-pass type I membrane protein. Endosome. Endosome membrane. Nucleus. Note=In response to EGF, translocated from the cell membrane to the nucleus via Golgi and ER. Endocytosed upon activation by ligand. Colocalized with GPER1 in the nucleus of estrogen agonist-induced cancer-associated fibroblasts (CAF).
Tissue Specificity	Ubiquitously expressed. Isoform 2 is also expressed in ovarian cancers. {ECO:0000269|PubMed:17671655}.
Top Pathways	Estrogen signaling pathway, Oxytocin signaling pathway, MicroRNAs in cancer, Proteoglycans in cancer, Central carbon metabolism in cancer

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SignalSilence ® EGF Receptor siRNA II - 6482 from Cell Signaling Technology Category siRNA Prices $256.00 Sizes 300 µl (3 nmol) Species Reactivities Human

SignalSilence ® EGF Receptor siRNA I - 6480 from Cell Signaling Technology Category siRNA Prices $256.00 Sizes 300 µl (3 nmol) Species Reactivities Human

EGFR CRISPR/Cas9 KO Plasmid (h) - sc-400015 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

EGFR HDR Plasmid (h) - sc-400015-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

EGFR Double Nickase Plasmid (h) - sc-400015-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

EGFR Double Nickase Plasmid (h2) - sc-400015-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

EGFR CRISPR Activation Plasmid (h) - sc-400015-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

EGFR CRISPR Activation Plasmid (h2) - sc-400015-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

EGFR Lentiviral Activation Particles (h) - sc-400015-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

EGFR Lentiviral Activation Particles (h2) - sc-400015-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

EGFR siRNA (h) - sc-29301 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

EGFR shRNA Plasmid (h) - sc-29301-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

EGFR shRNA (h) Lentiviral Particles - sc-29301-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

EGFR siRNA (h2) - sc-44340 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

EGFR shRNA Plasmid (h2) - sc-44340-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

EGFR shRNA (h2) Lentiviral Particles - sc-44340-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

EGFR RNAi - H00001956-R15 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

EGF R/ErbB1 RNAi - H00001956-R13 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU076761 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

MISSION® siRNA - SIHK0658 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK0659 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK0657 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

CompoZr® Knockout ZFN Kit - CKOZFN1244 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1244 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR10032 from Sigma-Aldrich Category miRNA Prices $350.00 Sizes hutr10032

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