Gene Symbol | TIMM22 |
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Entrez Gene | 29928 |
Alt Symbol | TEX4, TIM22 |
Species | Human |
Gene Type | protein-coding |
Description | translocase of inner mitochondrial membrane 22 homolog (yeast) |
Other Description | mitochondrial import inner membrane translocase subunit Tim22|putative membrane protein|testis-expressed sequence 4 |
Swissprots | Q9NWI8 Q9Y584 |
Accessions | EAW90637 EAW90638 Q9Y584 AF155330 AAD40106 AK000830 BAA91392 AK225453 BC002324 AAH02324 NM_013337 NP_037469 |
Function | Essential core component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. In the TIM22 complex, it constitutes the voltage-activated and signal-gated channel. Forms a twin-pore translocase that uses the membrane potential as external driving force in 2 voltage-dependent steps (By similarity). {ECO:0000250}. |
Subcellular Location | Mitochondrion inner membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. |
Tim22 CRISPR/Cas9 KO Plasmid (h) - sc-412048 from Santa Cruz Biotechnology
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Tim22 HDR Plasmid (h) - sc-412048-HDR from Santa Cruz Biotechnology
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Tim22 Double Nickase Plasmid (h) - sc-412048-NIC from Santa Cruz Biotechnology
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Tim22 Double Nickase Plasmid (h2) - sc-412048-NIC-2 from Santa Cruz Biotechnology
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Tim22 CRISPR Activation Plasmid (h) - sc-412048-ACT from Santa Cruz Biotechnology
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Tim22 CRISPR Activation Plasmid (h2) - sc-412048-ACT-2 from Santa Cruz Biotechnology
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Tim22 Lentiviral Activation Particles (h) - sc-412048-LAC from Santa Cruz Biotechnology
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Tim22 Lentiviral Activation Particles (h2) - sc-412048-LAC-2 from Santa Cruz Biotechnology
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Tim22 siRNA (h) - sc-94220 from Santa Cruz Biotechnology
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Tim22 shRNA Plasmid (h) - sc-94220-SH from Santa Cruz Biotechnology
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Tim22 shRNA (h) Lentiviral Particles - sc-94220-V from Santa Cruz Biotechnology
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TIMM22 RNAi - H00029928-R01 from Novus Biologicals
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MISSION® esiRNA - EHU160361 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN21360 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND21360 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR07596 from Sigma-Aldrich
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TIMM22 siRNA (Human) - CRH9275 from Cohesion Biosciences
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TIMM22 - MBS8223939 from MyBioSource
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shRNA set against Human TIMM22 (NM_013337.2) - SHH427420 from Creative biogene
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Human TIMM22 siRNA - orb269777 from Biorbyt
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TIMM22 shRNA Plasmid (Human) - CHH9275 from Cohesion Biosciences
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TIMM22 miRNA 3'UTR clone - MiUTR1H-10413 from Creative biogene
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