| Gene Symbol | GABARAPL1 |
|---|---|
| Entrez Gene | 23710 |
| Alt Symbol | APG8-LIKE, APG8L, ATG8, ATG8B, ATG8L, GEC1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | GABA(A) receptor-associated protein like 1 |
| Other Description | GABA(A) receptor-associated protein-like 1|GABARAPL1-a|GEC-1|early estrogen-regulated protein|gamma-aminobutyric acid receptor-associated protein-like 1|glandular epithelial cell protein 1 |
| Swissprots | Q6FIE6 B4E0Y7 Q9H0R8 |
| Accessions | EAW96164 EAW96165 EAW96166 EAW96167 EAW96168 EAW96169 EAW96170 Q9H0R8 AF087847 AAK20399 AF287012 AAK55962 AK056846 AK074195 AK092075 AK124150 AK303581 BAG64599 AK315418 BAG37807 AL136676 CAB66611 AM393185 CAL38063 AM393189 CAL38067 BC008891 BC009309 AAH09309 BC028315 AAH28315 BX648781 CR533480 CAG38511 DQ893103 ABM84029 DQ896375 ABM87374 JN663881 AEZ06294 XM_005253344 XP_005253401 NM_031412 NP_113600 |
| Function | Ubiquitin-like modifier that increases cell-surface expression of kappa-type opioid receptor through facilitating anterograde intracellular trafficking of the receptor. Involved in formation of autophagosomal vacuoles. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation. {ECO:0000269|PubMed:16431922, ECO:0000269|PubMed:20404487}. |
| Subcellular Location | Cytoplasm, cytoskeleton. Cytoplasmic vesicle membrane; Lipid-anchor. Endoplasmic reticulum {ECO:0000250}. Golgi apparatus {ECO:0000250}. Cytoplasmic vesicle, autophagosome. |
| Tissue Specificity | Ubiquitous. Expressed at very high levels in the brain, heart, peripheral blood leukocytes, liver, kidney, placenta and skeletal muscle. Expressed at very low levels in thymus and small intestine. In the brain, expression is particularly intense in motoneurons in the embryo and in neurons involved in somatomotor and neuroendocrine functions in the adult, particularly in the substantia nigra pars compacta. {ECO:0000269|PubMed:11374880, ECO:0000269|PubMed:11414770, ECO:0000269|PubMed:23690988}. |
| Top Pathways | GABAergic synapse, Regulation of autophagy |
GABARAPL1 CRISPR/Cas9 KO Plasmid (h) - sc-403288 from Santa Cruz Biotechnology
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GABARAPL1 HDR Plasmid (h) - sc-403288-HDR from Santa Cruz Biotechnology
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GABARAPL1 Double Nickase Plasmid (h) - sc-403288-NIC from Santa Cruz Biotechnology
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GABARAPL1 Double Nickase Plasmid (h2) - sc-403288-NIC-2 from Santa Cruz Biotechnology
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GABARAPL1 CRISPR Activation Plasmid (h) - sc-403288-ACT from Santa Cruz Biotechnology
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GABARAPL1 CRISPR Activation Plasmid (h2) - sc-403288-ACT-2 from Santa Cruz Biotechnology
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GABARAPL1 Lentiviral Activation Particles (h) - sc-403288-LAC from Santa Cruz Biotechnology
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GABARAPL1 Lentiviral Activation Particles (h2) - sc-403288-LAC-2 from Santa Cruz Biotechnology
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GABARAPL1 siRNA (h) - sc-105386 from Santa Cruz Biotechnology
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GABARAPL1 shRNA Plasmid (h) - sc-105386-SH from Santa Cruz Biotechnology
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GABARAPL1 shRNA (h) Lentiviral Particles - sc-105386-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU107971 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN9043 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND9043 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR08723 from Sigma-Aldrich
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GABARAPL1 siRNA (Human) - CRH8440 from Cohesion Biosciences
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GABARAPL1 - MBS8214466 from MyBioSource
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shRNA set against Human GABARAPL1 (NM_031412.2) - SHH298357 from Creative biogene
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shRNA set against Human GABARAPL1(NM_031412.2) - SHG080187 from Creative biogene
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GABARAPL1 shRNA Plasmid (Human) - CHH8440 from Cohesion Biosciences
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GABARAPL1 miRNA 3'UTR clone - MiUTR1H-03904 from Creative biogene
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