Gene Symbol | WASF3 |
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Entrez Gene | 10810 |
Alt Symbol | Brush-1, SCAR3, WAVE3 |
Species | Human |
Gene Type | protein-coding |
Description | WAS protein family, member 3 |
Other Description | WASP family Verprolin-homologous protein 3|protein WAVE-3|verprolin homology domain-containing protein 3|wiskott-Aldrich syndrome protein family member 3 |
Swissprots | O94974 Q86VQ2 Q9UPY6 |
Accessions | EAX08388 EAX08389 Q9UPY6 AB020707 BAA74923 AB026543 BAA81796 AF134305 AAD33054 AF454702 AAL51032 AK289845 BAF82534 AK294725 BAG57872 AL133590 BC050283 AAH50283 BU736040 S69790 XM_011534889 XP_011533191 XM_011534890 XP_011533192 NM_001291965 NP_001278894 NM_006646 NP_006637 |
Function | Downstream effector molecules involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape. {ECO:0000269|PubMed:17623672, ECO:0000269|PubMed:21834987}. |
Subcellular Location | Cytoplasm, cytoskeleton. |
Tissue Specificity | Expressed in ovary and brain. |
Top Pathways | Adherens junction, Fc gamma R-mediated phagocytosis, Choline metabolism in cancer |
WAVE3 CRISPR/Cas9 KO Plasmid (h) - sc-404650 from Santa Cruz Biotechnology
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WAVE3 HDR Plasmid (h) - sc-404650-HDR from Santa Cruz Biotechnology
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WAVE3 Double Nickase Plasmid (h) - sc-404650-NIC from Santa Cruz Biotechnology
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WAVE3 Double Nickase Plasmid (h2) - sc-404650-NIC-2 from Santa Cruz Biotechnology
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WAVE3 CRISPR Activation Plasmid (h) - sc-404650-ACT from Santa Cruz Biotechnology
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WAVE3 CRISPR Activation Plasmid (h2) - sc-404650-ACT-2 from Santa Cruz Biotechnology
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WAVE3 Lentiviral Activation Particles (h) - sc-404650-LAC from Santa Cruz Biotechnology
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WAVE3 Lentiviral Activation Particles (h2) - sc-404650-LAC-2 from Santa Cruz Biotechnology
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WAVE3 siRNA (h) - sc-44192 from Santa Cruz Biotechnology
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WAVE3 shRNA Plasmid (h) - sc-44192-SH from Santa Cruz Biotechnology
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WAVE3 shRNA (h) Lentiviral Particles - sc-44192-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU084471 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN22778 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND22778 from Sigma-Aldrich
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WASF3 siRNA (Human) - CRH7369 from Cohesion Biosciences
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WASF3 - MBS8205338 from MyBioSource
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shRNA set against Human WASF3 (NM_006646.5) - SHH445624 from Creative biogene
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WASF3 shRNA Plasmid (Human) - CHH7369 from Cohesion Biosciences
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