| Gene Symbol |
ASF1B
|
| Entrez Gene |
55723
|
| Alt Symbol |
CIA-II
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
anti-silencing function 1B histone chaperone
|
| Other Description |
ASF1 anti-silencing function 1 homolog B|CCG1-interacting factor A-II|anti-silencing function protein 1 homolog B|hAsf1|hAsf1b|hCIA-II|histone chaperone ASF1B
|
| Swissprots |
Q9NVZ0 Q9NVP2 Q53G51
|
| Accessions |
EAW84401 EAW84402 Q9NVP2 AB104486 BAC87709 AF279307 AAK82973 AK001288 BAA91602 AK001466 BAA91708 AK223080 BAD96800 AK302134 BAG63508 BC007726 AAH07726 BC010014 AAH10014 BC036521 AAH36521 CN426445 CR457235 CAG33516 DQ587892 GQ129346 ACT64480 GQ129347 ACT64481 NM_018154 NP_060624
|
| Function |
Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly. Cooperates with chromatin assembly factor 1 (CAF-1) to promote replication-dependent chromatin assembly. Does not participate in replication-independent nucleosome deposition which is mediated by ASF1A and HIRA. Required for spermatogenesis. {ECO:0000269|PubMed:11897662, ECO:0000269|PubMed:12842904, ECO:0000269|PubMed:14718166, ECO:0000269|PubMed:15664198, ECO:0000269|PubMed:16151251}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:12842904}.
|
| Tissue Specificity |
Highly expressed in testis and at lower levels in colon, small intestine and thymus. {ECO:0000269|PubMed:12842904}.
|
![Western Blot: ASF1b Overexpression Lysate (Adult Normal) [NBL1-07761] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for ASF1b.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/9549_ASF1b%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-07761-img0002.jpg)