Gene Symbol | ASF1B |
---|---|
Entrez Gene | 55723 |
Alt Symbol | CIA-II |
Species | Human |
Gene Type | protein-coding |
Description | anti-silencing function 1B histone chaperone |
Other Description | ASF1 anti-silencing function 1 homolog B|CCG1-interacting factor A-II|anti-silencing function protein 1 homolog B|hAsf1|hAsf1b|hCIA-II|histone chaperone ASF1B |
Swissprots | Q9NVZ0 Q9NVP2 Q53G51 |
Accessions | EAW84401 EAW84402 Q9NVP2 AB104486 BAC87709 AF279307 AAK82973 AK001288 BAA91602 AK001466 BAA91708 AK223080 BAD96800 AK302134 BAG63508 BC007726 AAH07726 BC010014 AAH10014 BC036521 AAH36521 CN426445 CR457235 CAG33516 DQ587892 GQ129346 ACT64480 GQ129347 ACT64481 NM_018154 NP_060624 |
Function | Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly. Cooperates with chromatin assembly factor 1 (CAF-1) to promote replication-dependent chromatin assembly. Does not participate in replication-independent nucleosome deposition which is mediated by ASF1A and HIRA. Required for spermatogenesis. {ECO:0000269|PubMed:11897662, ECO:0000269|PubMed:12842904, ECO:0000269|PubMed:14718166, ECO:0000269|PubMed:15664198, ECO:0000269|PubMed:16151251}. |
Subcellular Location | Nucleus {ECO:0000269|PubMed:12842904}. |
Tissue Specificity | Highly expressed in testis and at lower levels in colon, small intestine and thymus. {ECO:0000269|PubMed:12842904}. |