Gene Symbol | CYBA |
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Entrez Gene | 1535 |
Alt Symbol | p22-PHOX |
Species | Human |
Gene Type | protein-coding |
Description | cytochrome b-245, alpha polypeptide |
Other Description | cytochrome b light chain|cytochrome b(558) alpha chain|cytochrome b(558) alpha-subunit|cytochrome b, alpha polypeptide|cytochrome b-245 light chain|cytochrome b558 subunit alpha|flavocytochrome b-558 alpha polypeptide|neutrophil cytochrome b 22 kDa polypeptide|p22 phagocyte B-cytochrome|p22phox|superoxide-generating NADPH oxidase light chain subunit |
Swissprots | P13498 Q9BR72 Q14090 |
Accessions | AAM96953 ABF20535 EAW66793 EAW66794 EAW66795 EAW66796 P13498 AK097127 AK125578 AK300049 BAG61858 AK309030 BC006465 AAH06465 BC011565 BC028224 BC033739 BT006861 AAP35507 BX109994 DQ893235 ABM84161 DQ896565 ABM87564 M21186 AAA90925 XM_011522905 XP_011521207 NM_000101 NP_000092 |
Function | Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide. {ECO:0000269|PubMed:15824103}. |
Subcellular Location | Cell membrane {ECO:0000269|PubMed:15585859, ECO:0000269|PubMed:22808130}. |
Top Pathways | Leukocyte transendothelial migration, Leishmaniasis, Phagosome, Osteoclast differentiation |
p22-phox CRISPR/Cas9 KO Plasmid (h) - sc-400325 from Santa Cruz Biotechnology
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p22-phox HDR Plasmid (h) - sc-400325-HDR from Santa Cruz Biotechnology
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p22-phox Double Nickase Plasmid (h) - sc-400325-NIC from Santa Cruz Biotechnology
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p22-phox Double Nickase Plasmid (h2) - sc-400325-NIC-2 from Santa Cruz Biotechnology
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p22-phox CRISPR Activation Plasmid (h) - sc-400325-ACT from Santa Cruz Biotechnology
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p22-phox CRISPR Activation Plasmid (h2) - sc-400325-ACT-2 from Santa Cruz Biotechnology
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p22-phox Lentiviral Activation Particles (h) - sc-400325-LAC from Santa Cruz Biotechnology
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p22-phox Lentiviral Activation Particles (h2) - sc-400325-LAC-2 from Santa Cruz Biotechnology
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p22-phox siRNA (h) - sc-36149 from Santa Cruz Biotechnology
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p22-phox shRNA Plasmid (h) - sc-36149-SH from Santa Cruz Biotechnology
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p22-phox shRNA (h) Lentiviral Particles - sc-36149-V from Santa Cruz Biotechnology
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Cytochrome b245 alpha RNAi - H00001535-R01 from Novus Biologicals
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CompoZr® Knockout ZFN Kit - CKOZFN6855 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND6855 from Sigma-Aldrich
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CYBA siRNA (Human) - CRH1084 from Cohesion Biosciences
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CYBA - MBS8213157 from MyBioSource
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p22-phox CRISPR/Cas9 KO Plasmid (h2) - sc-400325-KO-2 from Santa Cruz Biotechnology
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p22-phox HDR Plasmid (h2) - sc-400325-HDR-2 from Santa Cruz Biotechnology
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CYBA shRNA Plasmid (Human) - CHH1084 from Cohesion Biosciences
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CYBA miRNA 3'UTR clone - MiUTR3H-10053 from Creative biogene
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