| Gene Symbol |
RANBP9
|
| Entrez Gene |
10048
|
| Alt Symbol |
BPM-L, BPM90, RANBPM, RanBP7
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
RAN binding protein 9
|
| Other Description |
Ran Binding Protein in the Microtubule organizing center|novel centrosomal protein RanBPM|ran binding protein, centrosomal|ran-binding protein 9|ran-binding protein M
|
| Swissprots |
A0PJA2 Q7LBR2 Q6P3T7 O94764 Q7Z7F9 Q96S59 B2R8E1
|
| Accessions |
EAW55341 EAW55342 EAW55343 EAW55344 EAW55345 Q96S59 AB008515 BAA23216 AB055311 BAB62525 AF064606 AAC17111 AF306510 AAK15469 AK313334 BAG36138 BC019886 AAH19886 BC052781 AAH52781 BC053374 BC063849 AAH63849 XM_006714945 XP_006715008 XM_011514205 XP_011512507 NM_005493 NP_005484
|
| Function |
May act as an adapter protein to couple membrane receptors to intracellular signaling pathways. May be involved in signaling of ITGB2/LFA-1 and other integrins. Enhances HGF-MET signaling by recruiting Sos and activating the Ras pathway. Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but not affect estrogen-induced transactivation. Stabilizes TP73 isoform Alpha, probably by inhibiting its ubiquitination, and increases its proapoptotic activity. Inhibits the kinase activity of DYRK1A and DYRK1B. Inhibits FMR1 binding to RNA (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cytoplasm, cytosol. Nucleus. Note==Predominantly cytoplasmic. A phosphorylated form is associated with the plasma membrane.
|
| Tissue Specificity |
Ubiquitously expressed, with highest levels in testes, placenta, heart, and muscle, and lowest levels in lung. Within the brain, expressed predominantly by neurons in the gray matter of cortex, the granular layer of cerebellum and the Purkinje cells. {ECO:0000269|PubMed:12147692, ECO:0000269|PubMed:12361945, ECO:0000269|PubMed:15381419}.
|