RB1CC1

Gene Symbol	RB1CC1
Entrez Gene	9821
Alt Symbol	ATG17, CC1, FIP200, PPP1R131
Species	Human
Gene Type	protein-coding
Description	RB1-inducible coiled-coil 1
Other Description	200 kDa FAK family kinase-interacting protein|FAK family kinase-interacting protein of 200 kDa|RB1-inducible coiled-coil protein 1|phosphatase 1, regulatory subunit 131
Swissprots	Q8TDY2 Q92601 Q86YR4 Q8WVU9
Accessions	EAW86719 EAW86720 EAW86721 Q8TDY2 AB059622 BAB69690 AK291699 BAF84388 AK294579 BAG57770 AK307436 AY173931 AAO17545 BC017556 AAH17556 BC032074 D86958 BAA13194 DA326842 DQ892402 ABM83328 Z35085 XM_011517643 XP_011515945 XM_011517644 XP_011515946 XM_011517645 XP_011515947 XM_011517646 XP_011515948 XM_011517647 XP_011515949 XM_011517648 XP_011515950 XM_011517649 XP_011515951 XM_011517650 XP_011515952 XR_928826 NM_001083617 NP_001077086 NM_014781 NP_055596
Function	Plays a role as a modulator of TGF-beta-signaling by restricting substrate specificity of RNF111. Involved in autophagy. Regulates early events but also late events of autophagosome formation through direct interaction with Atg16L1. Required for the formation of the autophagosome-like double- membrane structure that surrounds the Salmonella-containing vacuole (SCV) duting S.typhimurium infection and subsequent xenophagy. Autophagy positively regulates repair of DNA damage induced by ionizing radiation and negatively regulates apoptosis. Plays an indispensible role in fetal hematopoiesis and in the regulation of neuronal homeostasis (By similarity). Implicated in the regulation of RB1 expression. Functions as a DNA-binding transcription factor. Is a potent regulator of the RB1 pathway and a mediator that plays a crucial role in muscular differentiation. Expression is, thus, a prerequisite for myogenic differentiation. Inhibits PTK2/FAK1 and PTK2B/PYK2 activity and activation of downstre
Subcellular Location	Nucleus. Cytoplasm, cytosol. Preautophagosomal structure membrane; Peripheral membrane protein. Note=Under starvation conditions, is localized to puncate structures primarily representing the isolation membrane that sequesters a portion of the cytoplasm resulting in the formation of an autophagosome. {ECO:0000250}.
Tissue Specificity	Expression levels correlated closely with those of RB1 in cancer cell lines as well as in various normal human tissues. Abundantly expressed in human musculoskeletal and cultured osteosarcoma cells. {ECO:0000269|PubMed:11850849, ECO:0000269|PubMed:12163359}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

RB1CC1 / CC1 Antibody Blocking Peptide - LS-E1222 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

RB1CC1 / CC1 Antibody Blocking Peptide - LS-E18219 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

RB1CC1-Antibody-Center-Blocking-peptide - BP11791c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

FIP200-Antibody-Center-Blocking-Peptide - BP14323c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

RB1CC1 Blocking Peptide - 33R-8445 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

RB1CC1 fusion protein - ag10508 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

RB1CC1 fusion protein - ag10528 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

RB1CC1 fusion protein - ag15739 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

RB1CC1 fusion protein - Ag17208 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

RB1CC1 fusion protein - ag0003 from Proteintech Group Category Protein Source E. coli-derived, Species Human

Recombinant Human RB1-inducible coiled-coil protein 1(RB1CC1) ,partial - CSB-YP855061HU CSB-EP855061HU CSB-BP855061HU CSB-MP855061HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

RB1CC1 Recombinant Protein Antigen - NBP2-47312PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

RB1CC1 Recombinant Protein Antigen - NBP2-48572PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E. coli Species Human

RB1CC1 Peptide, Human - M34GP13023H from Creative Peptides Category Peptide Source Synthetic. Species Human

RB1-inducible coiled-coil protein 1 (RB1CC1), partial, Recombinant Protein - MBS1406844 from MyBioSource Category Protein Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

Recombinant Human RB1CC1 Protein (1241-1594 aa), His-Myc-tagged - RB1CC1-2673H from Creative Biomart Category Protein Source E. coli Species Human

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