RB1CC1

Gene Symbol	RB1CC1
Entrez Gene	9821
Alt Symbol	ATG17, CC1, FIP200, PPP1R131
Species	Human
Gene Type	protein-coding
Description	RB1-inducible coiled-coil 1
Other Description	200 kDa FAK family kinase-interacting protein|FAK family kinase-interacting protein of 200 kDa|RB1-inducible coiled-coil protein 1|phosphatase 1, regulatory subunit 131
Swissprots	Q8TDY2 Q92601 Q86YR4 Q8WVU9
Accessions	EAW86719 EAW86720 EAW86721 Q8TDY2 AB059622 BAB69690 AK291699 BAF84388 AK294579 BAG57770 AK307436 AY173931 AAO17545 BC017556 AAH17556 BC032074 D86958 BAA13194 DA326842 DQ892402 ABM83328 Z35085 XM_011517643 XP_011515945 XM_011517644 XP_011515946 XM_011517645 XP_011515947 XM_011517646 XP_011515948 XM_011517647 XP_011515949 XM_011517648 XP_011515950 XM_011517649 XP_011515951 XM_011517650 XP_011515952 XR_928826 NM_001083617 NP_001077086 NM_014781 NP_055596
Function	Plays a role as a modulator of TGF-beta-signaling by restricting substrate specificity of RNF111. Involved in autophagy. Regulates early events but also late events of autophagosome formation through direct interaction with Atg16L1. Required for the formation of the autophagosome-like double- membrane structure that surrounds the Salmonella-containing vacuole (SCV) duting S.typhimurium infection and subsequent xenophagy. Autophagy positively regulates repair of DNA damage induced by ionizing radiation and negatively regulates apoptosis. Plays an indispensible role in fetal hematopoiesis and in the regulation of neuronal homeostasis (By similarity). Implicated in the regulation of RB1 expression. Functions as a DNA-binding transcription factor. Is a potent regulator of the RB1 pathway and a mediator that plays a crucial role in muscular differentiation. Expression is, thus, a prerequisite for myogenic differentiation. Inhibits PTK2/FAK1 and PTK2B/PYK2 activity and activation of downstre
Subcellular Location	Nucleus. Cytoplasm, cytosol. Preautophagosomal structure membrane; Peripheral membrane protein. Note=Under starvation conditions, is localized to puncate structures primarily representing the isolation membrane that sequesters a portion of the cytoplasm resulting in the formation of an autophagosome. {ECO:0000250}.
Tissue Specificity	Expression levels correlated closely with those of RB1 in cancer cell lines as well as in various normal human tissues. Abundantly expressed in human musculoskeletal and cultured osteosarcoma cells. {ECO:0000269|PubMed:11850849, ECO:0000269|PubMed:12163359}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

RB1CC1 CRISPR/Cas9 KO Plasmid (h) - sc-416259 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

RB1CC1 HDR Plasmid (h) - sc-416259-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

RB1CC1 Double Nickase Plasmid (h) - sc-416259-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

RB1CC1 Double Nickase Plasmid (h2) - sc-416259-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

RB1CC1 CRISPR Activation Plasmid (h) - sc-416259-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

RB1CC1 CRISPR Activation Plasmid (h2) - sc-416259-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

RB1CC1 Lentiviral Activation Particles (h) - sc-416259-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

RB1CC1 Lentiviral Activation Particles (h2) - sc-416259-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

RB1CC1 siRNA (h) - sc-38211 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

RB1CC1 shRNA Plasmid (h) - sc-38211-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

RB1CC1 shRNA (h) Lentiviral Particles - sc-38211-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

MISSION® esiRNA - EHU043821 from Sigma-Aldrich Category siRNA Prices $250.00 Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN18008 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND18008 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR09148 from Sigma-Aldrich Category miRNA

RB1CC1 siRNA (Human) - CRH6577 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

RB1CC1 RNAi - H00009821-R02 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

RB1CC1 - MBS8200518 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human RB1CC1 (NM_014781.4) - SHH390312 from Creative biogene Category siRNA Species Reactivities Human

shRNA set against Human RB1CC1(NM_001083617.1) - SHR167640 from Creative biogene Category siRNA Species Reactivities Human

Human RB1CC1 siRNA - orb267079 from Biorbyt Category siRNA Prices $485.00, $629.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

RB1CC1 shRNA Plasmid (Human) - CHH6577 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

RB1CC1 miRNA 3'UTR clone - MiUTR1H-08662 from Creative biogene Species Reactivities Human

RB1CC1 miRNA 3'UTR clone - MiUTR1H-08663 from Creative biogene Species Reactivities Human

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