| Gene Symbol |
LDB3
|
| Entrez Gene |
11155
|
| Alt Symbol |
CMD1C, CMPD3, CYPHER, LDB3Z1, LDB3Z4, LVNC3, MFM4, ORACLE, PDLIM6, ZASP
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
LIM domain binding 3
|
| Other Description |
LIM domain-binding protein 3|PDZ and LIM domain 6|Z-band alternatively spliced PDZ motif protein|Z-band alternatively spliced PDZ-motif protein|cardiomyopathy, dilated 1C (autosomal dominant)|protein cypher
|
| Swissprots |
A2TDB7 Q9Y4Z5 B4E3K3 O75112 Q9Y4Z4 Q5K6P0 Q96FH2 A6NIV4 Q9Y4Z3 Q5K6N9 Q5K6P1
|
| Accessions |
ABN05284 EAW80322 EAW80323 EAW80324 EAW80325 EAW80326 EAW80327 EAW80328 EAW80329 O75112 AA180065 AB014513 BAA31588 AF086263 AF276807 AAQ14316 AF276808 AAQ14317 AF276809 AAQ14318 AJ133766 CAB46727 AJ133767 CAB46728 AJ133768 CAB46729 AK093184 AK294696 BAG57855 AK297871 BAG60197 AK300692 BAG62375 AK304760 BAG65515 AL601484 BC010929 AAH10929 BC023609 BC111457 AAI11458 DA762127 DA898241 DC357269 F33274 KF772970 AHB60054 XM_005269464 XP_005269521 XM_005269466 XP_005269523 XM_005269468 XP_005269525 XM_011539184 XP_011537486 XM_011539185 XP_011537487 XM_011539186 XP_011537488 XM_011539187 XP_011537489 XM_011539188 XP_011537490 XM_011539189 XP_011537491 XM_011539190 XP_011537492 XM_011539191 XP_011537493 XM_011539192 XP_011537494 XM_011539193 XP_011537495 XM_011539194 XP_011537496 XM_011539195 XP_011537497 NM_001080114 NP_001073583 NM_001080115 NP_001073584 NM_001080116 NP_001073585 NM_001171610 NP_001165081 NM_001171611 NP_001165082 NM_007078 NP_009009
|
| Function |
May function as an adapter in striated muscle to couple protein kinase C-mediated signaling via its LIM domains to the cytoskeleton. {ECO:0000305}.
|
| Subcellular Location |
Cytoplasm, perinuclear region {ECO:0000269|PubMed:10427098}. Cell projection, pseudopodium {ECO:0000269|PubMed:10427098}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:10427098}. Cytoplasm, myofibril, sarcomere, Z line {ECO:0000269|PubMed:10427098}. Note=Localized to the cytoplasm around nuclei and pseudopodia of undifferentiated cells and detected throughout the myotubes of differentiated cells. Colocalizes with ACTN2 at the Z-lines.
|
| Tissue Specificity |
Expressed primarily in skeletal muscle and to a lesser extent in heart. Also detected in brain and placenta. {ECO:0000269|PubMed:10427098}.
|