LDB3

Gene Symbol	LDB3
Entrez Gene	11155
Alt Symbol	CMD1C, CMPD3, CYPHER, LDB3Z1, LDB3Z4, LVNC3, MFM4, ORACLE, PDLIM6, ZASP
Species	Human
Gene Type	protein-coding
Description	LIM domain binding 3
Other Description	LIM domain-binding protein 3|PDZ and LIM domain 6|Z-band alternatively spliced PDZ motif protein|Z-band alternatively spliced PDZ-motif protein|cardiomyopathy, dilated 1C (autosomal dominant)|protein cypher
Swissprots	A2TDB7 Q9Y4Z5 B4E3K3 O75112 Q9Y4Z4 Q5K6P0 Q96FH2 A6NIV4 Q9Y4Z3 Q5K6N9 Q5K6P1
Accessions	ABN05284 EAW80322 EAW80323 EAW80324 EAW80325 EAW80326 EAW80327 EAW80328 EAW80329 O75112 AA180065 AB014513 BAA31588 AF086263 AF276807 AAQ14316 AF276808 AAQ14317 AF276809 AAQ14318 AJ133766 CAB46727 AJ133767 CAB46728 AJ133768 CAB46729 AK093184 AK294696 BAG57855 AK297871 BAG60197 AK300692 BAG62375 AK304760 BAG65515 AL601484 BC010929 AAH10929 BC023609 BC111457 AAI11458 DA762127 DA898241 DC357269 F33274 KF772970 AHB60054 XM_005269464 XP_005269521 XM_005269466 XP_005269523 XM_005269468 XP_005269525 XM_011539184 XP_011537486 XM_011539185 XP_011537487 XM_011539186 XP_011537488 XM_011539187 XP_011537489 XM_011539188 XP_011537490 XM_011539189 XP_011537491 XM_011539190 XP_011537492 XM_011539191 XP_011537493 XM_011539192 XP_011537494 XM_011539193 XP_011537495 XM_011539194 XP_011537496 XM_011539195 XP_011537497 NM_001080114 NP_001073583 NM_001080115 NP_001073584 NM_001080116 NP_001073585 NM_001171610 NP_001165081 NM_001171611 NP_001165082 NM_007078 NP_009009
Function	May function as an adapter in striated muscle to couple protein kinase C-mediated signaling via its LIM domains to the cytoskeleton. {ECO:0000305}.
Subcellular Location	Cytoplasm, perinuclear region {ECO:0000269|PubMed:10427098}. Cell projection, pseudopodium {ECO:0000269|PubMed:10427098}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:10427098}. Cytoplasm, myofibril, sarcomere, Z line {ECO:0000269|PubMed:10427098}. Note=Localized to the cytoplasm around nuclei and pseudopodia of undifferentiated cells and detected throughout the myotubes of differentiated cells. Colocalizes with ACTN2 at the Z-lines.
Tissue Specificity	Expressed primarily in skeletal muscle and to a lesser extent in heart. Also detected in brain and placenta. {ECO:0000269|PubMed:10427098}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Cypher CRISPR/Cas9 KO Plasmid (h) - sc-405337 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Cypher HDR Plasmid (h) - sc-405337-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Cypher Double Nickase Plasmid (h) - sc-405337-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Cypher Double Nickase Plasmid (h2) - sc-405337-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Cypher CRISPR Activation Plasmid (h) - sc-405337-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Cypher CRISPR Activation Plasmid (h2) - sc-405337-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Cypher Lentiviral Activation Particles (h) - sc-405337-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Cypher Lentiviral Activation Particles (h2) - sc-405337-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Cypher siRNA (h) - sc-77078 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Cypher shRNA Plasmid (h) - sc-77078-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Cypher shRNA (h) Lentiviral Particles - sc-77078-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

LDB3 RNAi - H00011155-R01V from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

LDB3 RNAi - H00011155-R01 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU082001 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN11618 from Sigma-Aldrich Category ZFN Kit

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND11618 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

LDB3 siRNA (Human) - CRH7636 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human LDB3 (NM_007078.2) - SHH329259 from Creative biogene Category siRNA Species Reactivities Human

shRNA set against Human LDB3(NM_007078.2) - SHH145109 from Creative biogene Category siRNA Species Reactivities Human

shRNA set against Human LDB3(NM_001080114.1) - SHH145127 from Creative biogene Category siRNA Species Reactivities Human

shRNA set against Human LDB3(NM_001080115.1) - SHH145181 from Creative biogene Category siRNA Species Reactivities Human

Human LDB3 siRNA - orb268138 from Biorbyt Category siRNA Prices $485.00, $629.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

LDB3 shRNA Plasmid (Human) - CHH7636 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

LDB3 miRNA 3'UTR clone - MiUTR1H-05620 from Creative biogene Species Reactivities Human

LDB3 miRNA 3'UTR clone - MiUTR1H-05621 from Creative biogene Species Reactivities Human

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