| Gene Symbol |
NCOR2
|
| Entrez Gene |
9612
|
| Alt Symbol |
CTG26, N-CoR2, SMAP270, SMRT, SMRTE, SMRTE-tau, TNRC14, TRAC, TRAC-1, TRAC1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
nuclear receptor corepressor 2
|
| Other Description |
CTG repeat protein 26|T3 receptor-associating factor|silencing mediator for retinoid and thyroid hormone receptors|thyroid-, retinoic-acid-receptor-associated corepressor
|
| Swissprots |
Q56D06 O00613 O15416 Q13354 Q9Y618 Q59GM0 Q9Y5U0 O15421
|
| Accessions |
EAW98448 EAW98449 EAW98450 EAW98451 EAW98452 EAW98453 Q9Y618 AB209089 BAD92326 AF113003 AAD20946 AF125672 AAD22973 AK127788 AY965853 AAX77219 BC004326 AAH04326 BC020427 BM687540 BU172348 BX390462 CA396349 CN423531 CX873148 L32841 S83390 AAB50847 U80750 AAB91446 X79269 NM_001077261 NP_001070729 NM_001206654 NP_001193583 NM_006312 NP_006303
|
| Function |
Transcriptional corepressor. Mediates the transcriptional repression activity of some nuclear receptors by promoting chromatin condensation, thus preventing access of the basal transcription. Isoform 1 and isoform 5 have different affinities for different nuclear receptors. Involved in the regulation BCL6-dependent of the germinal center (GC) reactions, mainly through the control of the GC B-cells proliferation and survival. {ECO:0000269|PubMed:18212045, ECO:0000269|PubMed:23911289}.
|
| Subcellular Location |
Nucleus.
|
| Tissue Specificity |
Ubiquitous. High levels of expression are detected in lung, spleen and brain.
|
| Top Pathways |
Notch signaling pathway, Epstein-Barr virus infection
|