Gene Symbol | SLC6A15 |
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Entrez Gene | 55117 |
Alt Symbol | NTT73, SBAT1, V7-3, hv7-3 |
Species | Human |
Gene Type | protein-coding |
Description | solute carrier family 6 (neutral amino acid transporter), member 15 |
Other Description | homolog of rat orphan transporter v7-3|orphan sodium- and chloride-dependent neurotransmitter transporter NTT73|orphan transporter v7-3|sodium- and chloride-dependent neurotransmitter transporter NTT73|sodium-coupled branched-chain amino-acid transporter 1|sodium-dependent neutral amino acid transporter B(0)AT2|sodium/chloride dependent neurotransmitter transporter Homo sapiens orphan neurotransmitter transporter NTT7|solute carrier family 6 (neurotransmitter transporter), member 15|solute carrier family 6 member 15|solute carrier family 6, member 15|transporter v7-3 |
Swissprots | A8K592 E7ESJ5 B7Z2P7 Q9H2J7 Q9H9F5 |
Accessions | EAW97388 EAW97389 EAW97390 Q9H2J7 AF265577 AAG41361 AF351619 AAN76519 AI368909 AK001178 BAA91536 AK022853 BAB14274 AK291207 BAF83896 AK294945 BAH11933 AL050066 BC022253 AAH22253 BC039443 BC045559 BC070040 AAH70040 BE535587 BM696062 CF529868 CR749673 CAH18464 DA247242 XM_011538523 XP_011536825 XM_011538524 XP_011536826 XM_011538525 XP_011536827 NM_001146335 NP_001139807 NM_018057 NP_060527 NM_182767 NP_877499 |
Function | Functions as a sodium-dependent neutral amino acid transporter. Exhibits preference for the branched-chain amino acids, particularly leucine, valine and isoleucine and methionine. Mediates the saturable, pH-sensitive and electrogenic cotransport of proline and sodium ions with a stoichiometry of 1:1. May have a role as transporter for neurotransmitter precursors into neurons. In contrast to other members of the neurotransmitter transporter family, does not appear to be chloride-dependent. {ECO:0000269|PubMed:16226721}. |
Subcellular Location | Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. |
Tissue Specificity | Almost exclusively expressed in the brain. {ECO:0000269|PubMed:16226721}. |
SLC6A15 CRISPR/Cas9 KO Plasmid (h) - sc-410592 from Santa Cruz Biotechnology
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SLC6A15 HDR Plasmid (h) - sc-410592-HDR from Santa Cruz Biotechnology
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SLC6A15 Double Nickase Plasmid (h) - sc-410592-NIC from Santa Cruz Biotechnology
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SLC6A15 Double Nickase Plasmid (h2) - sc-410592-NIC-2 from Santa Cruz Biotechnology
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SLC6A15 CRISPR Activation Plasmid (h) - sc-410592-ACT from Santa Cruz Biotechnology
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SLC6A15 CRISPR Activation Plasmid (h2) - sc-410592-ACT-2 from Santa Cruz Biotechnology
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SLC6A15 Lentiviral Activation Particles (h) - sc-410592-LAC from Santa Cruz Biotechnology
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SLC6A15 Lentiviral Activation Particles (h2) - sc-410592-LAC-2 from Santa Cruz Biotechnology
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SLC6A15 siRNA (h) - sc-95673 from Santa Cruz Biotechnology
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SLC6A15 shRNA Plasmid (h) - sc-95673-SH from Santa Cruz Biotechnology
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SLC6A15 shRNA (h) Lentiviral Particles - sc-95673-V from Santa Cruz Biotechnology
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SLC6A15 RNAi - H00055117-R02 from Novus Biologicals
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MISSION® esiRNA - EHU093701 from Sigma-Aldrich
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MISSION® esiRNA - EHU096791 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN19675 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND19675 from Sigma-Aldrich
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SLC6A15 siRNA (Human) - CRJ0481 from Cohesion Biosciences
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SLC6A15 RNAi - H00055117-R01 from Novus Biologicals
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SLC6A15 - MBS8226042 from MyBioSource
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shRNA set against Human SLC6A15 (NM_182767.5) - SHH411860 from Creative biogene
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SLC6A15 shRNA Plasmid (Human) - CHJ0481 from Cohesion Biosciences
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