IBTK

Gene Symbol IBTK
Entrez Gene 25998
Alt Symbol BTBD26, BTKI
Species Human
Gene Type protein-coding
Description inhibitor of Bruton agammaglobulinemia tyrosine kinase
Other Description BTK-binding protein|Bruton agammaglobulinemia tyrosine kinase inhibitor|inhibitor of Bruton tyrosine kinase|inhibitor of Bruton's tyrosine kinase|inhibitor of Bruton's tyrosine kinase-alpha|inhibitor of Bruton's tyrosine kinase-beta|inhibitor of Bruton's tyrosine kinase-gamma
Swissprots Q5TFD7 Q2QKU3 Q9Y3T8 Q8IUY7 Q8IUQ9 Q9HBI8 Q8TAI4 Q2QKU2 Q2QKU4 Q9P2D0 Q5TFD9
Accessions EAW48685 EAW48686 EAW48687 EAW48688 Q9P2D0 AB037838 BAA92655 AF235049 AAG27170 AJ420588 AJ420593 AK123460 AK126777 BAG54372 AL050018 CAB43239 BC012551 BC027483 BC027490 AAH27490 BC035860 BC038244 AAH38244 BC042171 AAH42171 BC092410 BC112929 BC113696 AAI13697 BC113698 AAI13699 BC143736 AAI43737 BC143745 AAI43746 BC143748 BM670666 CB265364 DQ005633 AAY55906 DQ005634 AAY55907 DQ005635 AAY55908 XM_006715453 XP_006715516 XM_006715454 XP_006715517 NM_001300906 NP_001287835 NM_015525 NP_056340
Function Acts as an inhibitor of BTK tyrosine kinase activity, thereby playing a role in B-cell development. Down-regulates BTK kinase activity, leading to interference with BTK-mediated calcium mobilization and NF-kappa-B-driven transcription. {ECO:0000269|PubMed:11577348}.
Subcellular Location Cytoplasm. Membrane; Peripheral membrane protein. Note=Translocates to the plasma membrane upon IgM stimulation.
Tissue Specificity Expressed in DeFew, HEK293T, HeLa and in Jurkat, MC3 and NB4 lymphoid cells (at protein level). Isoform 1 is the predominant isoform expressed in all examined tissues and cell lines. Highly expressed in hemopoietic tissues (fetal liver, spleen, lymph node, thymus, peripheral blood leukocytes and bone marrow). Weakly or not expressed in other tissues. {ECO:0000269|PubMed:11577348, ECO:0000269|PubMed:18596081}.

IBtk CRISPR/Cas9 KO Plasmid (h) - sc-407418 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

IBtk HDR Plasmid (h) - sc-407418-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

IBtk Double Nickase Plasmid (h) - sc-407418-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

IBtk Double Nickase Plasmid (h2) - sc-407418-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

IBtk CRISPR Activation Plasmid (h) - sc-407418-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

IBtk CRISPR Activation Plasmid (h2) - sc-407418-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

IBtk Lentiviral Activation Particles (h) - sc-407418-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

IBtk Lentiviral Activation Particles (h2) - sc-407418-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

IBtk siRNA (h) - sc-95065 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

IBtk shRNA Plasmid (h) - sc-95065-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

IBtk shRNA (h) Lentiviral Particles - sc-95065-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU028961 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN10425 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND10425 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR08645 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr08645

IBTK siRNA (Human) - CRH8641 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

IBTK - MBS8223686 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human IBTK (NM_015525.2) - SHH316345 from Creative biogene

Category siRNA
Species Reactivities Human

Human IBTK siRNA - orb269143 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

IBTK shRNA Plasmid (Human) - CHH8641 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

IBTK miRNA 3'UTR clone - MiUTR1H-04774 from Creative biogene

Species Reactivities Human
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