IBTK

Gene Symbol IBTK
Entrez Gene 25998
Alt Symbol BTBD26, BTKI
Species Human
Gene Type protein-coding
Description inhibitor of Bruton agammaglobulinemia tyrosine kinase
Other Description BTK-binding protein|Bruton agammaglobulinemia tyrosine kinase inhibitor|inhibitor of Bruton tyrosine kinase|inhibitor of Bruton's tyrosine kinase|inhibitor of Bruton's tyrosine kinase-alpha|inhibitor of Bruton's tyrosine kinase-beta|inhibitor of Bruton's tyrosine kinase-gamma
Swissprots Q5TFD7 Q2QKU3 Q9Y3T8 Q8IUY7 Q8IUQ9 Q9HBI8 Q8TAI4 Q2QKU2 Q2QKU4 Q9P2D0 Q5TFD9
Accessions EAW48685 EAW48686 EAW48687 EAW48688 Q9P2D0 AB037838 BAA92655 AF235049 AAG27170 AJ420588 AJ420593 AK123460 AK126777 BAG54372 AL050018 CAB43239 BC012551 BC027483 BC027490 AAH27490 BC035860 BC038244 AAH38244 BC042171 AAH42171 BC092410 BC112929 BC113696 AAI13697 BC113698 AAI13699 BC143736 AAI43737 BC143745 AAI43746 BC143748 BM670666 CB265364 DQ005633 AAY55906 DQ005634 AAY55907 DQ005635 AAY55908 XM_006715453 XP_006715516 XM_006715454 XP_006715517 NM_001300906 NP_001287835 NM_015525 NP_056340
Function Acts as an inhibitor of BTK tyrosine kinase activity, thereby playing a role in B-cell development. Down-regulates BTK kinase activity, leading to interference with BTK-mediated calcium mobilization and NF-kappa-B-driven transcription. {ECO:0000269|PubMed:11577348}.
Subcellular Location Cytoplasm. Membrane; Peripheral membrane protein. Note=Translocates to the plasma membrane upon IgM stimulation.
Tissue Specificity Expressed in DeFew, HEK293T, HeLa and in Jurkat, MC3 and NB4 lymphoid cells (at protein level). Isoform 1 is the predominant isoform expressed in all examined tissues and cell lines. Highly expressed in hemopoietic tissues (fetal liver, spleen, lymph node, thymus, peripheral blood leukocytes and bone marrow). Weakly or not expressed in other tissues. {ECO:0000269|PubMed:11577348, ECO:0000269|PubMed:18596081}.

IBtk (A-14) - sc-168122 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-IBTK antibody - ab107852 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-IBTK antibody (ab107852) at 1/100 dilution + MDA-MB435 cell line lysates at 35 µg

Anti-IBTK Antibody (aa586-613, Biotin) - LS-C215206 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-IBTK Antibody (aa586-613, FITC) - LS-C215207 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-IBTK Antibody (aa586-613, Azide-free, HRP) - LS-C215208 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-IBTK Antibody (aa586-613, PE) - LS-C215209 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-IBTK Antibody (aa1-1353) - LS-C308363 from LifeSpan Bioscience

Prices $455.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal

Anti-IBTK Antibody (aa589-617) - LS-C322139 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-IBTK Antibody (C-Terminus) - LS-C345834 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot of IBTK Antibody with human 293T Whole Cell lysate.

Anti-IBTK Antibody (aa1050-1100) - LS-C289707 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Human IBtk by Western Blot and Immunoprecipitation. Samples: Whole cell lysate from HeLa (5, 15 and 50 ug for WB; 1 mg for IP, 20% of IP loaded) and 293T (T; 50 ug) cells. Antibodies: Affinity purified rabbit anti-IBtk antibody used for WB at 0.1 ug/ml (A) and 0.4 ug/ml (B) and used for IP at 6 ug/mg lysate. IBtk was also immunoprecipitated by rabbit anti-IBtk antibody BL10880, which recognizes an upstream epitope. Detection: Chemiluminescence with exposure times of 3 minutes (A) and 10 seconds (B).

Anti-IBTK Antibody (aa586-613) - LS-C165102 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
IBTK antibody immunohistochemistry of formalin-fixed and paraffin-embedded human lymph tissue followed by peroxidase-conjugated secondary antibody and DAB staining.

Anti-IBTK Antibody (aa586-613, AP) - LS-C215203 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-IBTK Antibody (aa586-613, APC) - LS-C215205 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-IBTK Antibody (aa1205-1217) - LS-C18986 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

IBTK Antibody - NBP1-88512 from Novus Biologicals

Prices $129.00, $419.00
Sizes 25 µl, 100 µl
Host Rabbit
Clonality Polyclonal
Immunocytochemistry/Immunofluorescence: IBTK Antibody [NBP1-88512] - Immunofluorescent staining of human cell line A-431 shows localization to nucleoplasm.

IBTK Antibody - NBP1-50033 from Novus Biologicals

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: IBTK Antibody [NBP1-50033] - Detection of Human IBtk by Western Blot and Immunoprecipitation. Samples: Whole cell lysate from HeLa (5, 15 and 50 mcg for WB; 1 mg for IP, 20% of IP loaded) and 293T (T; 50 mcg) cells. Antibodies: Affinity purified rabbit anti-IBtk antibody used for WB at 0.1 mcg/ml (A) and 0.4 mcg/ml (B) and used for IP at 6 mcg/mg lysate. IBtk was also immunoprecipitated by rabbit anti-IBtk antibody BL10880, which recognizes an upstream epitope. For blotting immunoprecipitated IBtk, the ReliaBLOT Reagents and Procedures were used. Detection: Chemiluminescence with exposure times of 3 minutes (A) and 10 seconds (B).

IBTK Antibody - NBP2-38581 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry: IBTK Antibody [NBP2-38581] - Staining of human bone marrow shows strong cytoplasmic positivity in hematopoietic cells.

IBTK Antibody - H00025998-B01P from Novus Biologicals

Prices $349.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
Western Blot: IBTK Antibody [H00025998-B01P] - analysis of IBTK expression in transfected 293T cell line by IBTK MaxPab polyclonal antibody. Lane 1: IBTK transfected lysate (148.83 KDa). Lane 2: Non-transfected lysate.

IBTK Antibody - NBP1-78061 from Novus Biologicals

Prices $399.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Rabbit Anti-IBTK Polyclonal Antibody - bs-15532R from Bioss

Prices $245.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

ANTI-IBTK (CENTER) antibody produced in rabbit - SAB1307151 from Sigma-Aldrich

Prices $326.00
Sizes 40 tst
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-IBTK (Center): <B>Cat. No. SAB1307151</B>: IBTK Antibody (Center) western blot analysis in MDA-MB435 cell line lysates (35 μg/lane).

Anti-IBTK antibody produced in mouse - SAB1407274 from Sigma-Aldrich

Prices $347.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-IBTK: <B>Cat. No. SAB1407274</B>: Antibody concentration: 0.1-5 μg/mL. Specific band of ~148.8 kDa using IBTK transfected 293T lysate.<BR/><B>Lanes</B><BR/>1. Transfected 293T lysate.<BR/>2. Non-transfected 293T lysate.

Anti-IBTK antibody produced in rabbit - HPA023826 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-IBTK: <B>Cat. No. HPA023826</B>: Immunohistochemical staining of human pancreas shows strong cytoplasmic positivity in exocrine glandular cells.

IBTK Antibody - C-terminal region (ARP75515_P050) - ARP75515_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

IBTK Antibody - middle region (OAAB00748) - OAAB00748 from Aviva Systems Biology

Prices $289.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
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