| Gene Symbol | AP3M2 |
|---|---|
| Entrez Gene | 10947 |
| Alt Symbol | AP47B, CLA20, P47B |
| Species | Human |
| Gene Type | protein-coding |
| Description | adaptor-related protein complex 3, mu 2 subunit |
| Other Description | AP-3 complex subunit mu-2|HA1 47 kDa subunit homolog 2|HA1 47kDA subunit homolog 2|adapter-related protein complex 3 mu-2 subunit|adapter-related protein complex 3 subunit mu-2|adaptor-related protein complex 3 subunit mu-2|clathrin assembly protein assembly protein complex 1 medium chain homolog 2|clathrin assembly protein assembly protein complex 3 mu-2 medium chain|clathrin coat assembly protein AP47 homolog 2|clathrin coat-associated protein AP47 homolog 2|clathrin-associated protein AP47 homolog 2|golgi adaptor AP-1 47 kDA protein homolog 2|mu3B-adaptin |
| Swissprots | Q7Z472 D3DSY2 P53677 B2RCR0 |
| Accessions | CAR81021 CBX84499 EAW63236 EAW63237 EAW63238 P53677 AA854640 AK315228 BAG37657 BC021966 BC056257 AAH56257 BC056398 AAH56398 BI461390 BX648354 BX648390 D38293 BAA07415 EU832294 ACE87551 EU832378 ACE86863 NM_001134296 NP_001127768 NM_006803 NP_006794 |
| Function | Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. |
| Subcellular Location | Golgi apparatus. Cytoplasmic vesicle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex. {ECO:0000250}. |
| Top Pathways | Lysosome |
AP-3μ2 CRISPR/Cas9 KO Plasmid (h) - sc-411541 from Santa Cruz Biotechnology
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AP-3μ2 HDR Plasmid (h) - sc-411541-HDR from Santa Cruz Biotechnology
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AP-3μ2 Double Nickase Plasmid (h) - sc-411541-NIC from Santa Cruz Biotechnology
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AP-3μ2 Double Nickase Plasmid (h2) - sc-411541-NIC-2 from Santa Cruz Biotechnology
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AP-3μ2 CRISPR Activation Plasmid (h) - sc-411541-ACT from Santa Cruz Biotechnology
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AP-3μ2 CRISPR Activation Plasmid (h2) - sc-411541-ACT-2 from Santa Cruz Biotechnology
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AP-3μ2 Lentiviral Activation Particles (h) - sc-411541-LAC from Santa Cruz Biotechnology
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AP-3μ2 Lentiviral Activation Particles (h2) - sc-411541-LAC-2 from Santa Cruz Biotechnology
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AP-3μ2 siRNA (h) - sc-105075 from Santa Cruz Biotechnology
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AP-3μ2 shRNA Plasmid (h) - sc-105075-SH from Santa Cruz Biotechnology
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AP-3μ2 shRNA (h) Lentiviral Particles - sc-105075-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU155661 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN3296 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND3296 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR10998 from Sigma-Aldrich
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AP3M2 siRNA (Human) - CRH7469 from Cohesion Biosciences
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AP3M2 - MBS8201642 from MyBioSource
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shRNA set against Human AP3M2 (NM_006803.3) - SHH237926 from Creative biogene
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Human AP3M2 siRNA - orb267971 from Biorbyt
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AP3M2 shRNA Plasmid (Human) - CHH7469 from Cohesion Biosciences
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