Gene Symbol | AP3M2 |
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Entrez Gene | 10947 |
Alt Symbol | AP47B, CLA20, P47B |
Species | Human |
Gene Type | protein-coding |
Description | adaptor-related protein complex 3, mu 2 subunit |
Other Description | AP-3 complex subunit mu-2|HA1 47 kDa subunit homolog 2|HA1 47kDA subunit homolog 2|adapter-related protein complex 3 mu-2 subunit|adapter-related protein complex 3 subunit mu-2|adaptor-related protein complex 3 subunit mu-2|clathrin assembly protein assembly protein complex 1 medium chain homolog 2|clathrin assembly protein assembly protein complex 3 mu-2 medium chain|clathrin coat assembly protein AP47 homolog 2|clathrin coat-associated protein AP47 homolog 2|clathrin-associated protein AP47 homolog 2|golgi adaptor AP-1 47 kDA protein homolog 2|mu3B-adaptin |
Swissprots | Q7Z472 D3DSY2 P53677 B2RCR0 |
Accessions | CAR81021 CBX84499 EAW63236 EAW63237 EAW63238 P53677 AA854640 AK315228 BAG37657 BC021966 BC056257 AAH56257 BC056398 AAH56398 BI461390 BX648354 BX648390 D38293 BAA07415 EU832294 ACE87551 EU832378 ACE86863 NM_001134296 NP_001127768 NM_006803 NP_006794 |
Function | Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. |
Subcellular Location | Golgi apparatus. Cytoplasmic vesicle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex. {ECO:0000250}. |
Top Pathways | Lysosome |
AP-3μ (K-20) - sc-46770 from Santa Cruz Biotechnology
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AP-3μ (N-18) - sc-46771 from Santa Cruz Biotechnology
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Anti-AP3M2 antibody - ab87092 from Abcam
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Anti-AP3M2 antibody - ab68535 from Abcam
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Anti-AP3M2 antibody [EPR12965] - N-terminal - ab180138 from Abcam
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Anti-AP3M2 antibody [EPR12966] - ab182000 from Abcam
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Anti-AP3M2 Antibody (aa143-192) - LS-C102417 from LifeSpan Bioscience
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AP3M2 Antibody - NBP1-56624 from Novus Biologicals
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AP3M2 Antibody - 21070002 from Novus Biologicals
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AP3M2 Antibody - NBP2-15419 from Novus Biologicals
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AP3M2 Antibody - H00010947-B01 from Novus Biologicals
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AP3M2 Antibody - H00010947-B01P from Novus Biologicals
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Anti-AP3M2 antibody produced in mouse - SAB1408801 from Sigma-Aldrich
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Anti-AP3M2 antibody produced in rabbit - SAB2701229 from Sigma-Aldrich
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Anti-AP3M2 antibody produced in rabbit - SAB2103383 from Sigma-Aldrich
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AP3M2 antibody - middle region (ARP52255_P050) - ARP52255_P050 from Aviva Systems Biology
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ap3m2 antibody - zf125281 from GeneTex
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AP3M2 antibody [N1C1] - GTX115508 from GeneTex
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AP3M2 antibody - 70R-3582 from Fitzgerald
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AP3 complex subunit mu-2 / AP3M2 antibody - AP44887PU-N from Acris Antibodies
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AP3 complex subunit mu-2 / AP3M2 antibody - H00010947-B01 from Acris Antibodies
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AP3 complex subunit mu-2 / AP3M2 antibody - H00010947-B01P from Acris Antibodies
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AP3M2 antibody - 11925-1-AP from Acris Antibodies
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AP3M2 Antibody - 26-638 from ProSci
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AP3M2 antibody - 11925-1-AP from Proteintech Group
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