| Gene Symbol |
CACNA1F
|
| Entrez Gene |
778
|
| Alt Symbol |
AIED, COD3, COD4, CORDX, CORDX3, CSNB2, CSNB2A, CSNBX2, Cav1.4, Cav1.4alpha1, JM8, JMC8, OA2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
calcium channel, voltage-dependent, L type, alpha 1F subunit
|
| Other Description |
voltage-dependent L-type calcium channel subunit alpha-1F|voltage-gated calcium channel subunit alpha Cav1.4
|
| Swissprots |
O60840 O43901 A6NI29 F5CIQ9 Q9UHB1 O95226
|
| Accessions |
AAB92359 CAA06916 EAW50677 EAW50678 EAW50679 EAW50680 EAW50681 EAW50682 EAW50683 O60840 AA019975 AF067227 AAD03587 AF201304 AAF15290 AJ224874 CAA12175 BM931932 JF701915 AED89557 XM_011543983 XP_011542285 NM_001256789 NP_001243718 NM_001256790 NP_001243719 NM_005183 NP_005174
|
| Function |
Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1F gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to omega-conotoxin- GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA).
|
| Subcellular Location |
Membrane; Multi-pass membrane protein.
|
| Tissue Specificity |
Expression in skeletal muscle and retina. {ECO:0000269|PubMed:10873387}.
|
| Top Pathways |
Alzheimer's disease, Arrhythmogenic right ventricular cardiomyopathy (ARVC), cAMP signaling pathway, MAPK signaling pathway, Calcium signaling pathway
|
