Gene Symbol | CACNA1F |
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Entrez Gene | 778 |
Alt Symbol | AIED, COD3, COD4, CORDX, CORDX3, CSNB2, CSNB2A, CSNBX2, Cav1.4, Cav1.4alpha1, JM8, JMC8, OA2 |
Species | Human |
Gene Type | protein-coding |
Description | calcium channel, voltage-dependent, L type, alpha 1F subunit |
Other Description | voltage-dependent L-type calcium channel subunit alpha-1F|voltage-gated calcium channel subunit alpha Cav1.4 |
Swissprots | O60840 O43901 A6NI29 F5CIQ9 Q9UHB1 O95226 |
Accessions | AAB92359 CAA06916 EAW50677 EAW50678 EAW50679 EAW50680 EAW50681 EAW50682 EAW50683 O60840 AA019975 AF067227 AAD03587 AF201304 AAF15290 AJ224874 CAA12175 BM931932 JF701915 AED89557 XM_011543983 XP_011542285 NM_001256789 NP_001243718 NM_001256790 NP_001243719 NM_005183 NP_005174 |
Function | Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1F gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to omega-conotoxin- GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA). |
Subcellular Location | Membrane; Multi-pass membrane protein. |
Tissue Specificity | Expression in skeletal muscle and retina. {ECO:0000269|PubMed:10873387}. |
Top Pathways | Alzheimer's disease, Arrhythmogenic right ventricular cardiomyopathy (ARVC), cAMP signaling pathway, MAPK signaling pathway, Calcium signaling pathway |
L-type Ca ++ CP α1F (H-160) - sc-25688 from Santa Cruz Biotechnology
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L-type Ca ++ CP α1F (H-16) - sc-32074 from Santa Cruz Biotechnology
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L-type Ca ++ CP α1F (N-20) - sc-16252 from Santa Cruz Biotechnology
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Anti-CACNA1F antibody - ab54918 from Abcam
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Anti-CACNA1F antibody [EPR11822] - ab171968 from Abcam
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Anti-CACNA1F / Cav1.4 Antibody (aa1700-1750) - LS-C94032 from LifeSpan Bioscience
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Anti-CACNA1F / Cav1.4 Antibody (clone 3B2) - LS-C139182 from LifeSpan Bioscience
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Cav1.4 Antibody - NBP1-20107 from Novus Biologicals
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Cav1.4 Antibody - NBP1-30667 from Novus Biologicals
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Cav1.4 Antibody (3B2) - H00000778-M01J from Novus Biologicals
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Cav1.4 Antibody - H00000778-A01 from Novus Biologicals
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Cav1.4 Antibody (3B2) - H00000778-M01A from Novus Biologicals
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CACNA1F Polyclonal Antibody - bs-11245R from Bioss
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CACNA1F Polyclonal Antibody, ALEXA FLUOR® 350 Conjugated - bs-11245R-A350 from Bioss
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CACNA1F Polyclonal Antibody, ALEXA FLUOR® 488 Conjugated - bs-11245R-A488 from Bioss
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CACNA1F Polyclonal Antibody, ALEXA FLUOR® 555 Conjugated - bs-11245R-A555 from Bioss
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CACNA1F Polyclonal Antibody, ALEXA FLUOR® 647 Conjugated - bs-11245R-A647 from Bioss
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CACNA1F Polyclonal Antibody, Cy3 Conjugated - bs-11245R-Cy3 from Bioss
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CACNA1F Polyclonal Antibody, Cy5 Conjugated - bs-11245R-Cy5 from Bioss
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CACNA1F Polyclonal Antibody, Cy5.5 Conjugated - bs-11245R-Cy5.5 from Bioss
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CACNA1F Polyclonal Antibody, Cy7 Conjugated - bs-11245R-Cy7 from Bioss
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CACNA1F Polyclonal Antibody, FITC Conjugated - bs-11245R-FITC from Bioss
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CACNA1F Polyclonal Antibody, Biotin Conjugated - bs-11245R-Biotin from Bioss
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CACNA1F Polyclonal Antibody, HRP Conjugated - bs-11245R-HRP from Bioss
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Monoclonal Anti-CACNA1F, (C-terminal) antibody produced in mouse - SAB1403627 from Sigma-Aldrich
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