XPO1
| Gene Symbol | XPO1 |
|---|---|
| Entrez Gene | 7514 |
| Alt Symbol | CRM1, emb, exp1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | exportin 1 |
| Other Description | chromosome region maintenance 1 homolog|chromosome region maintenance 1 protein homolog|exportin 1 (CRM1 homolog, yeast)|exportin-1|exportin-1 (required for chromosome region maintenance) |
| Swissprots | A6NL14 O14980 Q63HP8 A8K1K5 Q68CP3 Q99433 D6W5E2 |
| Accessions | AAY14949 EAW99993 EAW99994 EAW99995 O14980 AK094339 AK124769 BAG54092 AK289920 BAF82609 AK299039 BAG61113 AK312426 AK316481 BAH14852 AL833550 BC032847 AAH32847 BX492941 BX643790 BX647758 CAH56174 BX954288 CR749840 CAH18695 D89729 BAA23415 DQ891271 ABM82197 Y08614 CAA69905 XM_005264544 XP_005264601 XM_005264546 XP_005264603 XM_006712094 XP_006712157 XM_011533097 XP_011531399 XM_011533098 XP_011531400 XM_011533099 XP_011531401 NM_003400 NP_003391 |
| Function | Mediates the nuclear export of cellular proteins (cargos) bearing a leucine-rich nuclear export signal (NES) and of RNAs. In the nucleus, in association with RANBP3, binds cooperatively to the NES on its target protein and to the GTPase RAN in its active GTP-bound form (Ran-GTP). Docking of this complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Involved in U3 snoRNA transport from Cajal bodies to nucleoli. Binds to late precursor U3 snoRNA bearing a TMG cap. Several viruses, among them HIV-1, HTLV-1 and influenza A use it to export their unspliced or incompletely |
| Subcellular Location | Cytoplasm. Nucleus, nucleoplasm. Nucleus, Cajal body. Nucleus, nucleolus. Note=Located in the nucleoplasm, Cajal bodies and nucleoli. Shuttles between the nucleus/nucleolus and the cytoplasm. |
| Tissue Specificity | Expressed in heart, brain, placenta, lung, liver, skeletal muscle, pancreas, spleen, thymus, prostate, testis, ovary, small intestine, colon and peripheral blood leukocytes. Not expressed in the kidney. {ECO:0000269|PubMed:9049309, ECO:0000269|PubMed:9368044}. |
| Top Pathways | RNA transport, Ribosome biogenesis in eukaryotes, HTLV-I infection, Influenza A, Epstein-Barr virus infection |
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