XPO1

Gene Symbol	XPO1
Entrez Gene	7514
Alt Symbol	CRM1, emb, exp1
Species	Human
Gene Type	protein-coding
Description	exportin 1
Other Description	chromosome region maintenance 1 homolog|chromosome region maintenance 1 protein homolog|exportin 1 (CRM1 homolog, yeast)|exportin-1|exportin-1 (required for chromosome region maintenance)
Swissprots	A6NL14 O14980 Q63HP8 A8K1K5 Q68CP3 Q99433 D6W5E2
Accessions	AAY14949 EAW99993 EAW99994 EAW99995 O14980 AK094339 AK124769 BAG54092 AK289920 BAF82609 AK299039 BAG61113 AK312426 AK316481 BAH14852 AL833550 BC032847 AAH32847 BX492941 BX643790 BX647758 CAH56174 BX954288 CR749840 CAH18695 D89729 BAA23415 DQ891271 ABM82197 Y08614 CAA69905 XM_005264544 XP_005264601 XM_005264546 XP_005264603 XM_006712094 XP_006712157 XM_011533097 XP_011531399 XM_011533098 XP_011531400 XM_011533099 XP_011531401 NM_003400 NP_003391
Function	Mediates the nuclear export of cellular proteins (cargos) bearing a leucine-rich nuclear export signal (NES) and of RNAs. In the nucleus, in association with RANBP3, binds cooperatively to the NES on its target protein and to the GTPase RAN in its active GTP-bound form (Ran-GTP). Docking of this complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Involved in U3 snoRNA transport from Cajal bodies to nucleoli. Binds to late precursor U3 snoRNA bearing a TMG cap. Several viruses, among them HIV-1, HTLV-1 and influenza A use it to export their unspliced or incompletely
Subcellular Location	Cytoplasm. Nucleus, nucleoplasm. Nucleus, Cajal body. Nucleus, nucleolus. Note=Located in the nucleoplasm, Cajal bodies and nucleoli. Shuttles between the nucleus/nucleolus and the cytoplasm.
Tissue Specificity	Expressed in heart, brain, placenta, lung, liver, skeletal muscle, pancreas, spleen, thymus, prostate, testis, ovary, small intestine, colon and peripheral blood leukocytes. Not expressed in the kidney. {ECO:0000269|PubMed:9049309, ECO:0000269|PubMed:9368044}.
Top Pathways	RNA transport, Ribosome biogenesis in eukaryotes, HTLV-I infection, Influenza A, Epstein-Barr virus infection

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

CRM1 (A-7) - sc-374124 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

CRM1 (C-1) - sc-74454 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

CRM1 (H-7) - sc-74455 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

CRM1 (G-9) - sc-373865 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

CRM1 (C-20) - sc-7825 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

CRM1 (H-300) - sc-5595 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

CRM1 (N-19) - sc-7826 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Anti-CRM1 [EPR14124] antibody - C-terminal - ab191081 from Abcam Prices $384.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EPR14124

Anti-CRM1 antibody - ab24189 from Abcam Prices $395.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-CRM1 antibody - ab84375 from Abcam Prices $376.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-CRM1 antibody [EPR14123(B)] - ab180144 from Abcam Prices $384.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EPR14123(B)

Anti-XPO1 / CRM1 Antibody (aa375-425) - LS-C287376 from LifeSpan Bioscience Prices $375.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-XPO1 / CRM1 Antibody (C-Terminus) IHC-plus™ - LS-B11039 from LifeSpan Bioscience Prices $395.00 Sizes 50 µl Host Rabbit Clonality Polyclonal

Anti-XPO1 / CRM1 Antibody (aa809-858) - LS-C80338 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-XPO1 / CRM1 Antibody - LS-C330908 from LifeSpan Bioscience Prices $305.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-XPO1 / CRM1 Antibody (C-Terminus) - LS-C110522 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-XPO1 / CRM1 Antibody (aa390-408) IHC-plus™ - LS-B1776 from LifeSpan Bioscience Prices $395.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-XPO1 / CRM1 Antibody (aa817-846) - LS-C98422 from LifeSpan Bioscience Prices $295.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-XPO1 / CRM1 Antibody (C-Terminus) IHC-plus™ - LS-B11299 from LifeSpan Bioscience Prices $395.00 Sizes 50 µl Host Rabbit Clonality Polyclonal

CRM1 Antibody - NB100-79802 from Novus Biologicals Prices $359.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

CRM1 Antibody - NB100-56493 from Novus Biologicals Prices $99.00, $229.00 Sizes 25 µg, 100 µg Host Rabbit Clonality Polyclonal

CRM1 Antibody - NBP2-33381 from Novus Biologicals Prices $419.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

CRM1 Antibody - NBP2-16014 from Novus Biologicals Prices $329.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

CRM1 Antibody - NB100-40862 from Novus Biologicals Prices $399.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

CRM1 Antibody - NB100-79811 from Novus Biologicals Prices $359.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

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