ACD

Gene Symbol	ACD
Entrez Gene	65057
Alt Symbol	PIP1, PTOP, TINT1, TPP1
Species	Human
Gene Type	protein-coding
Description	adrenocortical dysplasia homolog (mouse)
Other Description	POT1 and TIN2 organizing protein|POT1 and TIN2-interacting protein|TIN2 interacting protein 1|adrenocortical dysplasia protein homolog
Swissprots	Q9H8F9 Q562H5 Q96AP0
Accessions	AAX82621 EAW83154 EAW83155 Q96AP0 AF070535 AK023726 BAB14658 AK125623 AK301090 BAG62692 AY502940 AAS80318 BC016904 AAH16904 DB040017 XM_005256115 XP_005256172 XR_429727 XR_429728 NM_001082486 NP_001075955 NM_001082487 NP_001075956 NM_022914 NP_075065
Function	Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Promotes binding of POT1 to single-stranded telomeric DNA. Modulates the inhibitory effects of POT1 on telomere elongation. The ACD-POT1 heterodimer enhances telomere elongation by increasing telomerase processivity. Plays a role in shelterin complex assembly. May play a role in organogenesis. {ECO:0000269|PubMed:15181449, ECO:0000269|PubMed:16166375, ECO:0000269|PubMed:16880378, ECO:0000269|PubMed:17237768, ECO:0000269|PubMed:20231318}.
Subcellular Location	Nucleus {ECO:0000269|PubMed:15181449}. Chromosome, telomere {ECO:0000269|PubMed:15181449}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

ACD Lysate(Denatured) - H00065057-T01 from Acris Antibodies Category Cell Lysate Prices $320.00 Sizes 100 µl

ACD overexpression lysate - LY402957 from Acris Antibodies Category Cell Lysate Prices $480.00 Sizes 100 µg

ACD overexpression lysate - LY421183 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

ACD overexpression lysate - LY421184 from Acris Antibodies Category Cell Lysate Prices $480.00 Sizes 100 µg

ACD 293 Cell Lysate - 402575 from ABBIOTEC Category Cell Lysate Prices $672.00 Sizes 100 µg Species Mouse

ACD 293 Cell Lysate - 409496 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg Species Mouse

ACD Overexpression Lysate (Denatured) - H00065057-T01 from Novus Biologicals Category Cell Lysate Prices $279.00 Sizes 100 µl

ACD Overexpression Lysate (Native) - NBL1-07235 from Novus Biologicals Category Cell Lysate Prices $529.00 Sizes 100 µg

ACD Overexpression Lysate (Native) - NBL1-07236 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

ACD Over-expression Lysate Product - GWB-D7628B from Genway Biotech Category Cell Lysate Prices $346.00 Sizes 100 µg Species Human

ACD Over-expression Lysate Product - GWB-9A380F from Genway Biotech Category Cell Lysate Prices $756.00 Sizes 100 µg Species Human

Human TPP1 / CLN2 Insect Cell Lysate (WB positive control) - 13507-H08BL-300 from Sino Biological Category Cell Lysate Prices $195.00 Sizes 300 µg Species Human

ACD Overexpression Lysate (Denatured) - H00065057-T02 from Novus Biologicals Category Cell Lysate Prices $299.00 Sizes 100 µl

Human TPP1 Baculovirus-Insect Cells Transfected Lysate (positive control) (denatured) - orb175163 from Biorbyt Category Cell Lysate Prices $604.00 Sizes 300 μg Species Human

Panoply™ Human ACD Knockdown Stable Cell Line - CSC-DC000128 from Creative biogene Category Cell Line Species Human

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