ACD

Gene Symbol ACD
Entrez Gene 65057
Alt Symbol PIP1, PTOP, TINT1, TPP1
Species Human
Gene Type protein-coding
Description adrenocortical dysplasia homolog (mouse)
Other Description POT1 and TIN2 organizing protein|POT1 and TIN2-interacting protein|TIN2 interacting protein 1|adrenocortical dysplasia protein homolog
Swissprots Q9H8F9 Q562H5 Q96AP0
Accessions AAX82621 EAW83154 EAW83155 Q96AP0 AF070535 AK023726 BAB14658 AK125623 AK301090 BAG62692 AY502940 AAS80318 BC016904 AAH16904 DB040017 XM_005256115 XP_005256172 XR_429727 XR_429728 NM_001082486 NP_001075955 NM_001082487 NP_001075956 NM_022914 NP_075065
Function Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Promotes binding of POT1 to single-stranded telomeric DNA. Modulates the inhibitory effects of POT1 on telomere elongation. The ACD-POT1 heterodimer enhances telomere elongation by increasing telomerase processivity. Plays a role in shelterin complex assembly. May play a role in organogenesis. {ECO:0000269|PubMed:15181449, ECO:0000269|PubMed:16166375, ECO:0000269|PubMed:16880378, ECO:0000269|PubMed:17237768, ECO:0000269|PubMed:20231318}.
Subcellular Location Nucleus {ECO:0000269|PubMed:15181449}. Chromosome, telomere {ECO:0000269|PubMed:15181449}.

TPP1 (D4E2R) Rabbit mAb - 14667 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D4E2R
Western blot analysis of extracts from various cell lines using TPP1 (D4E2R) Rabbit mAb (upper) and β-Actin (D6A8) Rabbit mAb #8457 (lower).

ACD (F-12) - sc-163619 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

ACD (AA-2) - sc-100597 from Santa Cruz Biotechnology

Prices $295.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
ACD (AA-2): sc-100597. Western blot analysis of ACD expression in IMR-32 whole cell lysate.

Anti-PTOP antibody - ab57595 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
PTOP antibody (ab57595) used in immunofluorescence at 10ug/ml on HeLa cells.

Anti-PTOP antibody - ab112050 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-PTOP antibody (ab112050) at 0.4 µg/mlLane 1 : Jurkat whole cell lysate at 50 µgLane 2 : Jurkat whole cell lysate at 15 µgLane 3 : Jurkat whole cell lysate at 5 µgLane 4 : HeLa whole cell lysate at 50 µgdeveloped using the ECL technique

Anti-PTOP antibody - ab100855 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-PTOP antibody (ab100855) at 1/500 dilutionLane 1 : Human fetal brain lysateLane 2 : human fetal lung lysateLane 3 : human fetal kidney lysate

Anti-ACD / PTOP Antibody (clone 1D8-1B6) - LS-C133807 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 1D8-1B6
Immunoperoxidase of monoclonal antibody to ACD on formalin-fixed paraffin-embedded human heart tissue. [antibody concentration 2 ug/ml].

Anti-ACD / PTOP Antibody (clone 2B1) - LS-C173789 from LifeSpan Bioscience

Prices $350.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 2B1
IHC of paraffin-embedded Adenocarcinoma of Human endometrium tissue using anti-ACD mouse monoclonal antibody.

Anti-ACD / PTOP Antibody (aa1-545, Azide-free) - LS-C121326 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal

Anti-ACD / PTOP Antibody - LS-C137335 from LifeSpan Bioscience

Prices $255.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-ACD / PTOP Antibody (aa467-516) - LS-C108067 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
ACD / PTOP antibody LS-C108067 Western blot of NCI-H226 cell lysate.

Anti-ACD / PTOP Antibody - LS-C309294 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-ACD / PTOP Antibody - LS-C306050 from LifeSpan Bioscience

Prices $455.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal

Anti-ACD / PTOP Antibody (aa66-348) - LS-C311880 from LifeSpan Bioscience

Prices $250.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-ACD / PTOP Antibody (C-Terminus) - LS-C115987 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
ACD / PTOP antibody LS-C115987 Western blot of Mouse Muscle lysate.

Anti-ACD / PTOP Antibody (aa398-447) - LS-C82017 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Fetal brain lysate. Antibody concentration: 1.0 ug/ml. Gel concentration: 12%.

Anti-ACD / PTOP Antibody (clone 1C8) - LS-C337608 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 1C8
Anti-ACD mouse monoclonal antibody immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY ACD.

Anti-ACD / PTOP Antibody (clone 1A2) - LS-C337656 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 1A2
Anti-ACD mouse monoclonal antibody immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY ACD.

ACD Antibody (1D8-1B6) - H00065057-M02 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 1D8-1B6
Western Blot: ACD Antibody (1D8-1B6) [H00065057-M02] - Western Blot analysis of ACD expression in IMR-32 ( Cat # L008V1 ).

Tripeptidyl-Peptidase I/TPP1 Antibody - NBP1-31758 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: Tripeptidyl-Peptidase I/TPP1 Antibody [NBP1-31758] - Sample (30 ug of whole cell lysate) A: A431 B: H1299 C: Hela 7. 5% SDS PAGE; antibody diluted at 1:1000.

ACD Antibody - NBP1-53154 from Novus Biologicals

Prices $139.00, $329.00
Sizes 20 µl, 100 µl
Host Rabbit
Clonality Polyclonal

ACD Antibody (1A2) - NBP2-01851 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 1A2
Western Blot: ACD Antibody (1A2) [NBP2-01851] - HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY ACD (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-ACD.

ACD Antibody - NBP2-33839 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunocytochemistry/Immunofluorescence: ACD Antibody [NBP2-33839] - Immunofluorescent staining of human cell line U-2 OS shows localization to nuclear bodies.

PTOP Antibody - NBP1-32165 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: PTOP Antibody [NBP1-32165] - Sample(30 ug of whole cell lysate) A:Hep G2 7.5% SDS PAGE, antibody diluted at 1:500.

ACD Antibody - H00065057-B01P from Novus Biologicals

Prices $359.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
Western Blot: ACD Antibody [H00065057-B01P] - Analysis of ACD expression in HepG2.
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