| Gene Symbol | ARHGDIA |
|---|---|
| Entrez Gene | 396 |
| Alt Symbol | GDIA1, HEL-S-47e, NPHS8, RHOGDI, RHOGDI-1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | Rho GDP dissociation inhibitor (GDI) alpha |
| Other Description | GDP-dissociation inhibitor, aplysia RAS-related 1|epididymis secretory sperm binding protein Li 47e|rho GDP-dissociation inhibitor 1 |
| Swissprots | B4DUV9 A8MXW0 P52565 B2R5X1 B4DDD3 Q6IBM5 |
| Accessions | CAA45344 EAW89697 EAW89698 P52565 AF498926 AAM21074 AI391750 AI751683 AK293147 BAG56694 AK300816 BAG62471 AK312347 BAG35268 BC005851 AAH05851 BC005875 AAH05875 BC007630 BC008701 AAH08701 BC009759 AAH09759 BC013846 BC016031 AAH16031 BC016185 AAH16185 BC024258 AAH24258 BC027730 AAH27730 BC028333 BC075827 AAH75827 BC106044 AAI06045 BF343803 BI755343 BI768191 BM552638 BP325393 BQ674863 BT006884 AAP35530 CF132249 CF132324 CR456777 CAG33058 D13989 BAA03096 DA433004 DC406556 DQ891117 ABM82043 DQ894296 ABM85222 EU794615 ACJ13669 M97579 AAA36566 X69550 CAA49281 XM_011523574 XP_011521876 NM_001185077 NP_001172006 NM_001185078 NP_001172007 NM_001301240 NP_001288169 NM_001301241 NP_001288170 NM_001301242 NP_001288171 NM_001301243 NP_001288172 NM_004309 NP_004300 NR_125441 |
| Function | Controls Rho proteins homeostasis. Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Retains Rho proteins such as CDC42, RAC1 and RHOA in an inactive cytosolic pool, regulating their stability and protecting them from degradation. Actively involved in the recycling and distribution of activated Rho GTPases in the cell, mediates extraction from membranes of both inactive and activated molecules due its exceptionally high affinity for prenylated forms. Through the modulation of Rho proteins, may play a role in cell motility regulation. In glioma cells, inhibits cell migration and invasion by mediating the signals of SEMA5A and PLXNB3 that lead to inactivation of RAC1. {ECO:0000269|PubMed:20400958, ECO:0000269|PubMed:23434736}. |
| Subcellular Location | Cytoplasm {ECO:0000269|PubMed:23434736}. |
| Top Pathways | Neurotrophin signaling pathway, Vasopressin-regulated water reabsorption |