ARHGDIA

Gene Symbol ARHGDIA
Entrez Gene 396
Alt Symbol GDIA1, HEL-S-47e, NPHS8, RHOGDI, RHOGDI-1
Species Human
Gene Type protein-coding
Description Rho GDP dissociation inhibitor (GDI) alpha
Other Description GDP-dissociation inhibitor, aplysia RAS-related 1|epididymis secretory sperm binding protein Li 47e|rho GDP-dissociation inhibitor 1
Swissprots B4DUV9 A8MXW0 P52565 B2R5X1 B4DDD3 Q6IBM5
Accessions CAA45344 EAW89697 EAW89698 P52565 AF498926 AAM21074 AI391750 AI751683 AK293147 BAG56694 AK300816 BAG62471 AK312347 BAG35268 BC005851 AAH05851 BC005875 AAH05875 BC007630 BC008701 AAH08701 BC009759 AAH09759 BC013846 BC016031 AAH16031 BC016185 AAH16185 BC024258 AAH24258 BC027730 AAH27730 BC028333 BC075827 AAH75827 BC106044 AAI06045 BF343803 BI755343 BI768191 BM552638 BP325393 BQ674863 BT006884 AAP35530 CF132249 CF132324 CR456777 CAG33058 D13989 BAA03096 DA433004 DC406556 DQ891117 ABM82043 DQ894296 ABM85222 EU794615 ACJ13669 M97579 AAA36566 X69550 CAA49281 XM_011523574 XP_011521876 NM_001185077 NP_001172006 NM_001185078 NP_001172007 NM_001301240 NP_001288169 NM_001301241 NP_001288170 NM_001301242 NP_001288171 NM_001301243 NP_001288172 NM_004309 NP_004300 NR_125441
Function Controls Rho proteins homeostasis. Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Retains Rho proteins such as CDC42, RAC1 and RHOA in an inactive cytosolic pool, regulating their stability and protecting them from degradation. Actively involved in the recycling and distribution of activated Rho GTPases in the cell, mediates extraction from membranes of both inactive and activated molecules due its exceptionally high affinity for prenylated forms. Through the modulation of Rho proteins, may play a role in cell motility regulation. In glioma cells, inhibits cell migration and invasion by mediating the signals of SEMA5A and PLXNB3 that lead to inactivation of RAC1. {ECO:0000269|PubMed:20400958, ECO:0000269|PubMed:23434736}.
Subcellular Location Cytoplasm {ECO:0000269|PubMed:23434736}.
Top Pathways Neurotrophin signaling pathway, Vasopressin-regulated water reabsorption

RhoGDI Antibody - 2564 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of HeLa, NIH/3T3 and C6 cells, using RhoGDI Antibody.

Ly-GDI (D-7) - sc-271108 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Ly-GDI (D-7): sc-271108. Western blot analysis of Ly-GDI expression in non-transfected 293T: sc-117752 (A), mouse Ly-GDI transfected 293T: sc-121444 (B) and U-937 (C) whole cell lysates.

Rho GDI (E-1) - sc-373883 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Rho GDI (E-1): sc-373883. Western blot analysis of Rho GDIα expression in non-transfected: sc-110760 (A) and human Rho GDIα transfected: sc-112194 (B) 293 whole cell lysates.

Rho GDI (G-3) - sc-365190 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Rho GDI (G-3): sc-365190. Western blot analysis of Rho GDIα expression in non-transfected: sc-110760 (A) and human Rho GDIα transfected: sc-112194 (B) 293 whole cell lysates.

Rho GDI (FL-204) - sc-33201 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Rho GDI (FL-204): sc-33201. Western blot analysis of Rho GDI expression in HL-60 (A), HeLa (B) and SK-BR-3 (C) whole cell lysates.

Rho GDIα (B-10) - sc-13120 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Rho GDIα (B-10): sc-13120. Western blot analysis of Rho GDIα expression in non-transfected: sc-110760 (A) and human Rho GDIα transfected: sc-112194 (B) 293 whole cell lysates.

Rho GDIα (C-2) - sc-374579 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Rho GDIα (C-2): sc-374579. Western blot analysis of Rho GDIα expression in non-transfected 293: sc-110760 (A), human Rho GDIα transfected 293: sc-112194 (B) and Jurkat (C) whole cell lysates.

Rho GDIα (A-20) - sc-360 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Rho GDIα (A-20): sc-360. Western blot analysis of Rho GDIα expression in KNRK (A), PC-12 (B), HL-60 (C), HeLa (D), SK-BR-3 (E) and MCF7 (F) whole cell lysates.

Rho GDIα (G-10) - sc-373723 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Rho GDIα (G-10): sc-373723. Western blot analysis of Rho GDIα expression in MCF7 whole cell lysate.

Rho GDIα (G-2) - sc-373724 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Rho GDIα (G-2): sc-373724. Western blot analysis of Rho GDIα expression in K-562 (A) and MCF7 (B) whole cell lysates.

Rho GDIα (4A6) - sc-130341 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal

Rho GDIα (4A4) - sc-130340 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal

Rho GDIα (H-43) - sc-292544 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Rho GDIα (H-43): sc-292544. Western blot analysis of Rho GDIα expression in PC-12 (A) and SK-BR-3 (B) whole cell lysates.

Rho GDIα (K-21) - sc-359 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Rho GDIα (K-21): sc-359. Western blot analysis of Rho GDIα expression in HeLa (A), Jurkat (B), K-562 (C), A-431 (D) and NIH/3T3 (E) whole cell lysates.

p-Rho GDIα (Ser 101) - sc-33047 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

Anti-RhoGDI (phospho S174) antibody - ab74142 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-RhoGDI (phospho S174) antibody (ab74142) at 1/500 dilutionLane 1 : HUVEC cells treated with EGF (200ng/ml, 30mins)Lane 2 : HUVEC cells treated with EGF (200ng/ml, 30mins) with phosphopeptide at 10 µgLysates/proteins at 30 µg per lane.

Anti-RhoGDI antibody - ab175243 from Abcam

Prices $378.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunocytochemistry/Immunofluorescence analysis of HeLa cells using ab175243. Blue DAPI for nuclear staining.

Anti-RhoGDI antibody - ab154345 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-RhoGDI antibody (ab154345) at 1/500 dilution + IMR32 whole cell lysate at 30 µg

Anti-RhoGDI antibody - ab53850 from Abcam

Prices $373.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-RhoGDI antibody - ab52830 from Abcam

Prices $359.00
Sizes 100 µl
Host Mouse
Clonality Polyclonal
All lanes : Anti-RhoGDI antibody (ab52830) at 1/1000 dilutionLane 1 : a total protein extract from E coli with 50ng to 100 ng of a tagged fusion protein of an irrelevant antigenLane 2 : a total protein extract from E coli with 50ng to 500ng of the antigen (tagged antigen fusion protein)Lysates/proteins at 20 µg per lane.SecondaryRabbit anti-mouse IgG + IgM, (H+L) horseradish peroxidase at 1/5000 dilution

Anti-RhoGDI antibody - ab106242 from Abcam

Prices $376.00
Sizes 200 µl
Host Goat
Clonality Polyclonal
Anti-RhoGDI antibody (ab106242) at 1 µg/ml + Mouse Lung lysates (in RIPA buffer) at 35 µgdeveloped using the ECL technique

Anti-RhoGDI antibody - ab93735 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-RhoGDI antibody (ab93735) at 1/200 dilution + HeLa cell lysate

Anti-RhoGDI antibody - ab54840 from Abcam

Prices $376.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Western blot against tagged recombinant protein immunogen using ab54840 RhoGDI antibody at 1ug/ml.

Anti-RhoGDI antibody [1F2] - ab118159 from Abcam

Prices $376.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 1F2
All lanes : Anti-RhoGDI antibody [1F2] (ab118159) at 1/200 dilutionLane 1 : HEK293T cell lysate transfected with pCMV6-ENTRY controlLane 2 : HEK293T cell lysate transfected with pCMV6-ENTRY RhoGDI cDNALysates/proteins at 5 µg per lane.

Anti-RhoGDI antibody [2G3] - ab135252 from Abcam

Prices $392.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 2G3
Anti-RhoGDI antibody [2G3] (ab135252) at 1/500 dilution + Human RhoGDI recombinant protein.
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