COMT

Gene Symbol COMT
Entrez Gene 1312
Alt Symbol HEL-S-98n
Species Human
Gene Type protein-coding
Description catechol-O-methyltransferase
Other Description catechol O-methyltransferase|epididymis secretory sperm binding protein Li 98n
Swissprots Q9BWC7 A8MPV9 Q6ICE6 P21964 Q6IB07
Accessions AAP88929 AEA30239 AEA30240 AEA30241 CAA81263 EAX03010 EAX03011 P21964 AK130031 AK290440 BAF83129 BC000419 AAH00419 BC005867 AAH05867 BC011935 AAH11935 BC100018 AAI00019 BE386545 BE728779 BT007125 AAP35789 BX461394 CR456422 CAG30308 CR456997 CAG33278 CU012983 CAK54414 CU013271 CAK54713 DQ893411 ABM84337 DQ896732 ABM87731 EF103916 EF103917 EF103918 EF103919 EF103920 EF103921 EF103922 EF212883 ABN14343 EF217321 ABN14344 EF217322 ABN14345 FJ224345 ACI46037 FJ410131 ACJ38231 FJ410132 ACJ38232 M58525 AAA68929 M65212 AAA68927 M65213 AAA68928 XM_011529885 XP_011528187 XM_011529886 XP_011528188 XM_011529887 XP_011528189 XM_011529888 XP_011528190 XM_011529889 XP_011528191 XM_011529890 XP_011528192 XM_011529891 XP_011528193 NM_000754 NP_000745 NM_001135161 NP_001128633 NM_001135162 NP_001128634 NM_007310 NP_009294
Function Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol.
Subcellular Location Isoform Soluble: Cytoplasm.
Tissue Specificity Brain, liver, placenta, lymphocytes and erythrocytes.
Top Pathways Steroid hormone biosynthesis, Dopaminergic synapse, Tyrosine metabolism

COMT (D4N6M) Rabbit mAb - 14368 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D4N6M
Western blot analysis of extracts from K-562 and SH-SY5Y cell lines and human prostate using COMT (D4N6M) Rabbit mAb.

COMT (FL-271) - sc-25844 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
COMT (FL-271): sc-25844. Immunofluorescence staining of methanol-fixed HeLa cells showing cytoplasmic and membrane localization.

COMT (G-4) - sc-137253 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
COMT (G-4): sc-137253. Western blot analysis of COMT expression in K-562 whole cell lysate.

COMT (C-20) - sc-28119 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

COMT (N-19) - sc-28116 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
COMT (N-19): sc-28116. Western blot analysis of COMT expression in K-562 (A) and JAR (B) whole cell lysates.

Anti-COMT antibody - ab129504 from Abcam

Prices $384.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human breast carcinoma tissue labelling COMT with ab129504 at 1/1000 (1µg/ml). Detection: DAB.

Anti-COMT antibody - ab66073 from Abcam

Prices $376.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Anti-COMT antibody (ab66073) at 1 µg/ml + A431 cell lysate at 50 µgSecondaryGoat Anti-Mouse IgG (H&L)-HRP at 1/2500 dilution

Anti-COMT antibody - ab118888 from Abcam

Prices $376.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
ab118888, at 7.5 µg/ml, staining COMT in Formalin-fixed, Paraffin-embedded Human Adrenal tissue by Immunohistochemistry.

Anti-COMT antibody - ab118908 from Abcam

Prices $376.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Human Adrenal tissue, Formalin-Fixed, Paraffin-Embedded (FFPE) stained using ab118908 at a concentration of 5 µg/ml.

Anti-COMT antibody [EPR6490] - ab126618 from Abcam

Prices $385.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR6490
All lanes : Anti-COMT antibody [EPR6490] (ab126618) at 1/1000 dilutionLane 1 : Human fetal liver lysateLane 2 : A431 cell lysateLane 3 : MOLT4 cell lysateLane 4 : 293T cell lysateLysates/proteins at 10 µg per lane.SecondaryGoat Anti-rabbit HRP at 1/2000 dilution

Anti-COMT antibody [EPR6491(B)] - ab124813 from Abcam

Prices $385.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR6491(B)
All lanes : Anti-COMT antibody [EPR6491(B)] (ab124813) at 1/1000 dilutionLane 1 : Fetal Liver lysate Lane 2 : A431 cell lysate Lane 3 : MOLT4 cell lysateLysates/proteins at 10 µg per lane.developed using the ECL technique

Anti-COMT Antibody (Internal) IHC-plus™ - LS-A8833 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
Anti-COMT antibody LS-A8833 IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-COMT Antibody (C-Terminus) IHC-plus™ - LS-A8836 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
Anti-COMT antibody LS-A8836 IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-COMT Antibody (Internal) IHC-plus™ - LS-A8834 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
Anti-COMT antibody LS-A8834 IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-COMT Antibody (Internal) IHC-plus™ - LS-B4343 from LifeSpan Bioscience

Host Goat
Clonality Polyclonal
Anti-COMT antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B4343 concentration 3.75 ug/ml.

Anti-COMT Antibody (aa143-192) - LS-C107721 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
COMT antibody LS-C107721 Western blot of Fetal Stomach lysate.

Anti-COMT Antibody (Internal, clone EPR6491(B)) - LS-C138721 from LifeSpan Bioscience

Host Rabbit
Clonality Monoclonal
Clone [EPR6491(B)]
Western blot analysis on (A) fetal liver, (B) A431, and (C) Molt-4 lysates using anti-COMT antibody.

Anti-COMT Antibody - LS-C152844 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
WB: Serum Characterization by Western Blot

Anti-COMT Antibody (N-Terminus) IHC-plus™ - LS-B4880 from LifeSpan Bioscience

Host Goat
Clonality Polyclonal
Anti-COMT antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B4880 concentration 3.75 ug/ml.

Anti-COMT Antibody (aa1-183, clone 10B2573, Azide-free) - LS-C183530 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal
Clone 10B2573

Anti-COMT Antibody (Internal) IHC-plus™ - LS-A9797 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
Anti-COMT antibody LS-A9797 IHC of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-COMT Antibody (Internal, clone 15B) - LS-C191749 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
Clone 15B

Anti-COMT Antibody (Internal) IHC-plus™ - LS-A9769 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
Human, Prostate: Formalin-Fixed Parafin-Embedded (FFPE)

Anti-COMT Antibody (aa37-65) - LS-C157657 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal
COMT Antibody (Ascites)western blot of HeLa cell line lysates (35 ug/lane). The COMT antibody detected the COMT protein (arrow).

Anti-COMT Antibody - LS-C285642 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
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