| Gene Symbol | COMT |
|---|---|
| Entrez Gene | 1312 |
| Alt Symbol | HEL-S-98n |
| Species | Human |
| Gene Type | protein-coding |
| Description | catechol-O-methyltransferase |
| Other Description | catechol O-methyltransferase|epididymis secretory sperm binding protein Li 98n |
| Swissprots | Q9BWC7 A8MPV9 Q6ICE6 P21964 Q6IB07 |
| Accessions | AAP88929 AEA30239 AEA30240 AEA30241 CAA81263 EAX03010 EAX03011 P21964 AK130031 AK290440 BAF83129 BC000419 AAH00419 BC005867 AAH05867 BC011935 AAH11935 BC100018 AAI00019 BE386545 BE728779 BT007125 AAP35789 BX461394 CR456422 CAG30308 CR456997 CAG33278 CU012983 CAK54414 CU013271 CAK54713 DQ893411 ABM84337 DQ896732 ABM87731 EF103916 EF103917 EF103918 EF103919 EF103920 EF103921 EF103922 EF212883 ABN14343 EF217321 ABN14344 EF217322 ABN14345 FJ224345 ACI46037 FJ410131 ACJ38231 FJ410132 ACJ38232 M58525 AAA68929 M65212 AAA68927 M65213 AAA68928 XM_011529885 XP_011528187 XM_011529886 XP_011528188 XM_011529887 XP_011528189 XM_011529888 XP_011528190 XM_011529889 XP_011528191 XM_011529890 XP_011528192 XM_011529891 XP_011528193 NM_000754 NP_000745 NM_001135161 NP_001128633 NM_001135162 NP_001128634 NM_007310 NP_009294 |
| Function | Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol. |
| Subcellular Location | Isoform Soluble: Cytoplasm. |
| Tissue Specificity | Brain, liver, placenta, lymphocytes and erythrocytes. |
| Top Pathways | Steroid hormone biosynthesis, Dopaminergic synapse, Tyrosine metabolism |