Gene Symbol | NIPBL |
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Entrez Gene | 25836 |
Alt Symbol | CDLS, CDLS1, IDN3, IDN3-B, Scc2 |
Species | Human |
Gene Type | protein-coding |
Description | Nipped-B homolog (Drosophila) |
Other Description | SCC2 homolog|delangin|nipped-B-like protein|sister chromatid cohesion 2 homolog |
Swissprots | Q6N080 Q6KCD6 Q6ZT92 Q9Y6Y4 Q9Y6Y3 Q8N4M5 Q6KC79 Q7Z2E6 |
Accessions | EAW55948 EAW55949 EAW55950 Q6KC79 AA508213 AJ627032 CAF25290 AJ640137 CAG26691 AK002065 AK022659 AK023416 AK023710 AK126804 BAC86701 AK290347 BAF83036 AL137726 AY726600 BC032711 BC033847 AAH33847 BC063859 BC131490 AAI31491 BC146821 AAI46822 BK005151 DAA05331 BQ723324 BX538177 CAD98051 BX538178 CAD98052 BX640644 CAE45790 CN369580 KJ807789 KJ807790 KJ807791 KJ807792 XM_005248280 XP_005248337 XM_005248282 XP_005248339 XM_006714467 XP_006714530 XM_006714468 XP_006714531 XM_011514014 XP_011512316 XM_011514015 XP_011512317 NM_015384 NP_056199 NM_133433 NP_597677 |
Function | Probably plays a structural role in chromatin. Involved in sister chromatid cohesion, possibly by interacting with the cohesin complex (By similarity). {ECO:0000250}. |
Subcellular Location | Nucleus {ECO:0000250}. |
Tissue Specificity | Widely expressed. Highly expressed in heart, skeletal muscle, fetal and adult liver, fetal and adult kidney. Expressed at intermediates level in thymus, placenta, peripheral leukocyte and small intestine. Weakly or not expressed in brain, colon, spleen and lung. {ECO:0000269|PubMed:15146185, ECO:0000269|PubMed:15146186}. |
NIPBL CRISPR/Cas9 KO Plasmid (h) - sc-403371 from Santa Cruz Biotechnology
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NIPBL HDR Plasmid (h) - sc-403371-HDR from Santa Cruz Biotechnology
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NIPBL Double Nickase Plasmid (h) - sc-403371-NIC from Santa Cruz Biotechnology
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NIPBL Double Nickase Plasmid (h2) - sc-403371-NIC-2 from Santa Cruz Biotechnology
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NIPBL CRISPR Activation Plasmid (h) - sc-403371-ACT from Santa Cruz Biotechnology
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NIPBL CRISPR Activation Plasmid (h2) - sc-403371-ACT-2 from Santa Cruz Biotechnology
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NIPBL Lentiviral Activation Particles (h) - sc-403371-LAC from Santa Cruz Biotechnology
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NIPBL Lentiviral Activation Particles (h2) - sc-403371-LAC-2 from Santa Cruz Biotechnology
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NIPBL siRNA (h) - sc-75921 from Santa Cruz Biotechnology
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NIPBL shRNA Plasmid (h) - sc-75921-SH from Santa Cruz Biotechnology
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NIPBL shRNA (h) Lentiviral Particles - sc-75921-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU083971 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN15306 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND15306 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR07194 from Sigma-Aldrich
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NIPBL siRNA (Human) - CRH8532 from Cohesion Biosciences
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NIPBL RNAi - H00025836-R01 from Novus Biologicals
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NIPBL RNAi - H00025836-R02 from Novus Biologicals
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shRNA set against Human NIPBL (NM_015384.4) - SHH352544 from Creative biogene
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Human NIPBL siRNA - orb269034 from Biorbyt
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NIPBL shRNA Plasmid (Human) - CHH8532 from Cohesion Biosciences
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NIPBL miRNA 3'UTR clone - MiUTR3H-10139 from Creative biogene
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NIPBL miRNA 3'UTR clone - MiUTR3H-10140 from Creative biogene
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