Gene Symbol | ATP4A |
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Entrez Gene | 495 |
Alt Symbol | ATP6A |
Species | Human |
Gene Type | protein-coding |
Description | ATPase, H+/K+ exchanging, alpha polypeptide |
Other Description | ATPase, H+/K+ transporting, alpha polypeptide|H(+)-K(+)-ATPase alpha subunit|gastric H(+)/K(+) ATPase subunit alpha|gastric H+/K+ ATPase alpha subunit|gastric H,K-ATPase alpha subunit|gastric H,K-ATPase catalytic subunit|gastric hydrogen-potassium ATPase|potassium-transporting ATPase alpha chain 1|proton pump |
Swissprots | P20648 O00738 |
Accessions | AAA35577 AAA35988 AAA51010 AAB50172 AAB64182 P20648 AK058032 AK223259 BAD96979 AK308474 AL832971 CAH56338 BC167780 AAI67780 NM_000704 NP_000695 |
Function | Catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. Responsible for acid production in the stomach. |
Subcellular Location | Cell membrane; Multi-pass membrane protein. |
Tissue Specificity | Found in gastric mucosa. |
Top Pathways | Collecting duct acid secretion, Gastric acid secretion, Oxidative phosphorylation |
ATP4A CRISPR/Cas9 KO Plasmid (h) - sc-408711 from Santa Cruz Biotechnology
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ATP4A HDR Plasmid (h) - sc-408711-HDR from Santa Cruz Biotechnology
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ATP4A Double Nickase Plasmid (h) - sc-408711-NIC from Santa Cruz Biotechnology
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ATP4A Double Nickase Plasmid (h2) - sc-408711-NIC-2 from Santa Cruz Biotechnology
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ATP4A CRISPR Activation Plasmid (h) - sc-408711-ACT from Santa Cruz Biotechnology
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ATP4A CRISPR Activation Plasmid (h2) - sc-408711-ACT-2 from Santa Cruz Biotechnology
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ATP4A Lentiviral Activation Particles (h) - sc-408711-LAC from Santa Cruz Biotechnology
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ATP4A Lentiviral Activation Particles (h2) - sc-408711-LAC-2 from Santa Cruz Biotechnology
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ATP4A siRNA (h) - sc-97188 from Santa Cruz Biotechnology
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ATP4A shRNA Plasmid (h) - sc-97188-SH from Santa Cruz Biotechnology
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ATP4A shRNA (h) Lentiviral Particles - sc-97188-V from Santa Cruz Biotechnology
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ATP4A RNAi - H00000495-R02 from Novus Biologicals
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MISSION® esiRNA - EHU017011 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN3692 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND3692 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR03442 from Sigma-Aldrich
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ATP4A siRNA (Human) - CRH0348 from Cohesion Biosciences
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ATP4A - MBS8213632 from MyBioSource
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shRNA set against Human ATP4A (NM_000704.2) - SHH242710 from Creative biogene
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shRNA set against Human ATP4A(NM_000704.2) - SHG082087 from Creative biogene
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Human ATP4A siRNA - orb260850 from Biorbyt
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ATP4A shRNA Plasmid (Human) - CHH0348 from Cohesion Biosciences
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ATP4A miRNA 3'UTR clone - MiUTR1H-00689 from Creative biogene
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